Signalling, sorting and scaffolding adaptors for Toll-like receptors
Toll-like receptors (TLRs) are danger-sensing receptors that typically propagate self-limiting
inflammatory responses, but can unleash uncontrolled inflammation in non-homeostatic or …
inflammatory responses, but can unleash uncontrolled inflammation in non-homeostatic or …
Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and-independent secretion
IL-1β requires processing by caspase-1 to generate the active, pro-inflammatory cytokine.
Acute IL-1β secretion from inflammasome-activated macrophages requires caspase-1 …
Acute IL-1β secretion from inflammasome-activated macrophages requires caspase-1 …
APPLs: More than just adiponectin receptor binding proteins
Z Liu, T Xiao, X Peng, G Li, F Hu - Cellular signalling, 2017 - Elsevier
APPLs (adaptor proteins containing the pleckstrin homology domain, phosphotyrosine
binding domain and leucine zipper motif) are multifunctional adaptor proteins that bind to …
binding domain and leucine zipper motif) are multifunctional adaptor proteins that bind to …
The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages
Although mitophagy is known to restrict NLRP3 inflammasome activation, the underlying
regulatory mechanism remains poorly characterized. Here we describe a type of early …
regulatory mechanism remains poorly characterized. Here we describe a type of early …
运动与肠道菌健康效益的关系
梁家琪， 刘恒旭， 阳金鑫， 杨椅， 邓旭辉， 谭明健， 罗炯 - 中国组织工程研究, 2023 - cjter.com
运动与肠道菌健康效益的关系 中国组织工程研究 首页 关于本刊 编委会 在线投稿 期刊公告
出版道德 OA政策 作者学院 在线问答 联系我们 English 中国组织工程研究 ›› 2023, Vol. 27 ›› …
出版道德 OA政策 作者学院 在线问答 联系我们 English 中国组织工程研究 ›› 2023, Vol. 27 ›› …
Rab8a localisation and activation by Toll-like receptors on macrophage macropinosomes
Macropinocytosis is a prevalent and essential pathway in macrophages where it contributes
to anti-microbial responses and innate immune cell functions. Cell surface ruffles give rise to …
to anti-microbial responses and innate immune cell functions. Cell surface ruffles give rise to …
Glucocorticoid receptor ChIP-seq identifies PLCD1 as a KLF15 target that represses airway smooth muscle hypertrophy
SK Sasse, V Kadiyala, T Danhorn… - American journal of …, 2017 - atsjournals.org
Glucocorticoids exert important therapeutic effects on airway smooth muscle (ASM), yet few
direct targets of glucocorticoid signaling in ASM have been definitively identified. Here, we …
direct targets of glucocorticoid signaling in ASM have been definitively identified. Here, we …
APPL1 prevents pancreatic beta cell death and inflammation by dampening NFκB activation in a mouse model of type 1 diabetes
Aims/hypothesis Beta cell inflammation and demise is a feature of type 1 diabetes. The
insulin-sensitising molecule 'adaptor protein, phosphotyrosine interacting with PH domain …
insulin-sensitising molecule 'adaptor protein, phosphotyrosine interacting with PH domain …
Chromatin accessibility landscape of stromal subpopulations reveals distinct metabolic and inflammatory features of porcine subcutaneous and visceral adipose …
Background Fat accumulation in visceral adipose tissue (VAT) confers increased risk for
metabolic disorders of obesity, whereas accumulation of subcutaneous adipose tissue (SAT) …
metabolic disorders of obesity, whereas accumulation of subcutaneous adipose tissue (SAT) …
Adiponectin-mediated regulation of the adiponectin cascade in cardiovascular disease: Updates
A Hafiane - Biochemical and Biophysical Research …, 2023 - Elsevier
The endocrine function of white adipose tissue is characterized by the synthesis of one its
main hormones: adiponectin. Although the biological role of adiponectin has not been fully …
main hormones: adiponectin. Although the biological role of adiponectin has not been fully …