Osteoarthritis (OA) is a degenerative and chronic joint disease characterized by clinical
symptoms and distortion of joint tissues. It primarily damages joint cartilage, causing pain …

Induced pluripotent stem cell (iPSC)-based disease modelling and the cell replacement
therapy approach have proven to be very powerful and instrumental in biomedical research …

Regenerative medicine is a new and promising mode of therapy for patients who have
limited or no other options for the treatment of their illness. Due to their pleotropic therapeutic …

Polymorphic HLAs form the primary immune barrier to cell therapy. In addition, innate
immune surveillance impacts cell engraftment, yet a strategy to control both, adaptive and …

Human pluripotent stem cells (PSCs) are a leading candidate for cell-based therapies
because of their capacity for unlimited self renewal and pluripotent differentiation. These …

Synthetic biology aims to design or assemble existing bioparts or bio-components for useful
bioproperties. During the past decades, progresses have been made to build delicate …

Microencapsulation is an emerging process in which an active substance is entrapped in a
homogeneous or heterogeneous matrix to form capsules. This technique allows reducing …

Cell therapies offer the promise of treating and altering the course of diseases which cannot
be addressed adequately by existing pharmaceuticals. Cell therapies are a diverse group …

Background Mesenchymal stem cell (MSC)-derived exosomes have been recognized as
new candidates for the treatment of ischemic disease or injury and may be an alternative …

Although cellular therapies hold great promise for the treatment of human disease, results
from several initial clinical trials have not shown a level of efficacy required for their use as a …