Axotomy or crush of a peripheral nerve leads to degeneration of the distal nerve stump
referred to as Wallerian degeneration (WD). During WD a microen‐vironment is created that …

Alzheimer's disease (AD) represents the main form of dementia, and is a major public health
problem. Despite intensive research efforts, current treatments have only marginal …

We have previously demonstrated that astrocytes synthesize and secrete apolipoprotein E in
situ. In the present work, primary cultures of rat brain astrocytes were used to study …

After transection of the optic nerve (ON) in adult rats, retinal ganglion cells (RGC)
progressively degenerate until, after two months, a residual population of only about 5% of …

The most prevalent genetic risk factor for Alzheimer's disease (AD) is Apolipoprotein E
(ApoE), a gene located on chromosome 19 that encodes three alleles (e2, e3, and e4) that …

Recent work has demonstrated that apo E secretion and accumulation increase in the
regenerating peripheral nerve. The fact that apoE, in conjunction with apoA-I and LDL …

A 37-kDa glycoprotein has been described recently, whose synthesis is dramatically
increased after injury of the rat sciatic and optic nerves. Cells in the nerve sheath, distal to …

Human apolipoprotein (apo) E contains an amino-and a carboxyl-terminal domain, which
are connected by a hinge region (approximately residues 165 to 215). The interaction of the …

Abstract Apolipoprotein E4 (apoE4) is a major risk factor for Alzheimer's disease (AD).
Several hypotheses have been proposed to explain the association of the APOE ε4 allele …

In this report, we have identified two apolipoproteins (apo), apoD and apoA-IV, that, together
with the previously identified apoA-I and apoE, accumulate in the regenerating peripheral …