A mighty “protein extractor” of the cell: structure and function of the p97/CDC48 ATPase
p97/VCP (known as Cdc48 in S. cerevisiae or TER94 in Drosophila) is one of the most
abundant cytosolic ATPases. It is highly conserved from archaebacteria to eukaryotes. In …
abundant cytosolic ATPases. It is highly conserved from archaebacteria to eukaryotes. In …
[HTML][HTML] Control of p97 function by cofactor binding
A Buchberger, H Schindelin, P Hänzelmann - FEBS letters, 2015 - Elsevier
Abstract p97 (also known as Cdc48, Ter94, and VCP) is an essential, abundant and highly
conserved ATPase driving the turnover of ubiquitylated proteins in eukaryotes. Even though …
conserved ATPase driving the turnover of ubiquitylated proteins in eukaryotes. Even though …
Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding
INTRODUCTION Many cellular proteins are polyubiquitinated but cannot be directly
degraded by the proteasome because they are well folded, associated with binding …
degraded by the proteasome because they are well folded, associated with binding …
The AAA+ ATPase p97, a cellular multitool
L Stach, PS Freemont - Biochemical Journal, 2017 - portlandpress.com
The AAA+ (ATPases associated with diverse cellular activities) ATPase p97 is essential to a
wide range of cellular functions, including endoplasmic reticulum-associated degradation …
wide range of cellular functions, including endoplasmic reticulum-associated degradation …
Ubiquitin-and ATP-dependent unfoldase activity of P97/VCP• NPLOC4• UFD1L is enhanced by a mutation that causes multisystem proteinopathy
EE Blythe, KC Olson, V Chau… - Proceedings of the …, 2017 - National Acad Sciences
p97 is a “segregase” that plays a key role in numerous ubiquitin (Ub)-dependent pathways
such as ER-associated degradation. It has been hypothesized that p97 extracts proteins …
such as ER-associated degradation. It has been hypothesized that p97 extracts proteins …
Structure and function of the AAA+ ATPase p97/Cdc48p
D Xia, WK Tang, Y Ye - Gene, 2016 - Elsevier
Abstract p97 (also known as valosin-containing protein (VCP) in mammals or Cdc48p in
Saccharomyces cerevisiae) is an evolutionarily conserved ATPase present in all eukaryotes …
Saccharomyces cerevisiae) is an evolutionarily conserved ATPase present in all eukaryotes …
The interplay of cofactor interactions and post-translational modifications in the regulation of the AAA+ ATPase p97
P Hänzelmann, H Schindelin - Frontiers in molecular biosciences, 2017 - frontiersin.org
The hexameric type II AAA ATPase (ATPase associated with various activities) p97 (also
referred to as VCP, Cdc48, and Ter94) is critically involved in a variety of cellular activities …
referred to as VCP, Cdc48, and Ter94) is critically involved in a variety of cellular activities …
Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1–Npl4
Many polyubiquitinated proteins are extracted from membranes or complexes by the
conserved ATPase Cdc48 (in yeast; p97 or VCP in mammals) before proteasomal …
conserved ATPase Cdc48 (in yeast; p97 or VCP in mammals) before proteasomal …
Protein quality control of the endoplasmic reticulum and ubiquitin–proteasome-triggered degradation of aberrant proteins: yeast pioneers the path
N Berner, KR Reutter, DH Wolf - Annual review of biochemistry, 2018 - annualreviews.org
Cells must constantly monitor the integrity of their macromolecular constituents. Proteins are
the most versatile class of macromolecules but are sensitive to structural alterations …
the most versatile class of macromolecules but are sensitive to structural alterations …
Insights into adaptor binding to the AAA protein p97
HO Yeung, P Kloppsteck, H Niwa… - Biochemical Society …, 2008 - portlandpress.com
The AAA (ATPase associated with various cellular activities) p97 [also known as VCP
(valosin-containing protein)] participates in numerous biological activities and is an essential …
(valosin-containing protein)] participates in numerous biological activities and is an essential …