PLK1 is a conserved mitotic kinase that is essential for the entry into and progression
through mitosis. In addition to its canonical mitotic functions, recent studies have …

Centrosome abnormalities are the hallmark of cancer. How it affects tumorigenesis is still a
mystery. However, the presence of more than two centrosomes at the onset of mitosis often …

Cell polarity relies on the asymmetric distribution of the conserved PAR proteins, which is
regulated by phosphorylation/dephosphorylation reactions. While the kinases involved have …

The centrosome linker component C‐Nap1 (encoded by CEP250) anchors filaments to
centrioles that provide centrosome cohesion by connecting the two centrosomes of an …

Asymmetric cell division is the process in which one cell divides to give rise to two daughter
cells with different cell fates. This process is important throughout development and during …

Convergence and positioning of the pronuclei and mitotic spindle of many zygotes aids
efficient division and is essential for early embryonic patterning. In the C. elegans zygote …

Asymmetry within cells relies on the uneven distribution of molecules and organelles
required for cell function and viability. For example, epithelial cells form an apical …