Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy
characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and …

Autoantibodies are frequently observed in healthy individuals. In a minority of these
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …

The anti–von Willebrand factor nanobody caplacizumab was licensed for adults with
immune-mediated thrombotic thrombocytopenic purpura (iTTP) based on prospective …

Background Acquired thrombotic thrombocytopenic purpura (TTP) is caused by aggregation
of platelets on ultralarge von Willebrand factor multimers. This microvascular thrombosis …

Essentials• An international collaboration provides a consensus for clinical definitions.• This
concerns thrombotic microangiopathies and thrombotic thrombocytopenic purpura (TTP).• …

Atypical hemolytic uremic syndrome (aHUS) emerged during the last decade as a disease
largely of complement dysregulation. This advance facilitated the development of novel …

Thrombotic thrombocytopenic purpura (TTP; also known as Moschcowitz disease) is
characterized by the concomitant occurrence of often severe thrombocytopenia …

Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic
microangiopathy characterized by microangiopathic hemolytic anemia, severe …

Background Thrombotic thrombocytopenic purpura is a thrombotic microangiopathy related
to a severe deficiency of ADAMTS13 (a disintegrin and metalloprotease with …

The discovery of a disintegrin-like and metalloproteinase with thrombospondin type 1 motif,
member 13 (ADAMTS13) revolutionized our approach to thrombotic thrombocytopenic …