Membrane proteins play a most important part in metabolism, signaling, cell motility,
transport, development, and many other biochemical and biophysical processes which …

Membrane proteins have long presented a challenge to biochemical and functional studies.
In the absence of a bilayer environment, individual proteins and critical macromolecular …

A new and promising tool in membrane research is the detergent-free solubilization of
membrane proteins by styrene–maleic acid copolymers (SMAs). These amphipathic …

Membrane proteins (MPs) used to be the most difficult targets for structural biology when X-
ray crystallography was the mainstream approach. With the resolution revolution of single …

Nanotechnology is a multidisciplinary field that covers a vast and diverse array of devices
and machines derived from engineering, physics, materials science, chemistry and biology …

Apoptosis, a mechanism for programmed cell death, has key roles in human health and
disease. Many signals for cellular life and death are regulated by the BCL-2 family proteins …

Neurotransmitters are released through nascent fusion pores, which ordinarily dilate after
bilayer fusion, preventing consistent biochemical studies. We used lipid bilayer nanodiscs …

More than two dozen clinical syndromes known as amyloid diseases are characterized by
the buildup of extended insoluble fibrillar deposits in tissues. These amorphous Congo red …

Nanodiscs are self-assembled discoidal fragments of lipid bilayers 8–16 nm in diameter,
stabilized in solution by two amphipathic helical scaffold proteins. As stable and highly …

Photorhabdus luminescens is an insect pathogenic bacterium that is symbiotic with
entomopathogenic nematodes. On invasion of insect larvae, P. luminescens is released …