Thoracic aortic diseases, whether sporadic or due to a genetic disorder such as Marfan
syndrome, lack effective medical therapies, with limited translation of treatments that are …

Vascular tissue engineering combines cells with scaffold materials in vitro aiming the
development of physiologically relevant vascular models. For natural scaffolds such as …

Consumption of diets high in fat, sugar, and salt (Western diet, WD) is associated with
accelerated arterial stiffening, a major independent risk factor for cardiovascular disease …

Using a top-down approach, an agent-based model was developed within NetLogo where
cells and extracellular matrix (ECM) fibers were composed of multiple agents to create …

Microstructural properties of extracellular matrix (ECM) promote cell and tissue homeostasis
as well as contribute to the formation and progression of disease. In order to understand …

Abdominal aortic aneurysms (AAA) are common and potentially life-threatening aortic
dilatations, due to the effect of hemodynamic changes on the aortic wall. Previous research …

The bioassembly of layered tissue that closely mimics human histology presents challenges
for tissue engineering. Existing bioprinting technologies lack the resolution and cell …

Abstract Transient Receptor Potential Vanilloid‐type 4 (TRPV4) is a mechanosensitive,
Ca2+‐permeable plasma membrane channel that associates with focal adhesions …

Intrinsically poor auto-regenerative repair of proteolytically-disrupted elastic matrix structures
by resident SMCs in the wall of abdominal aortic aneurysms (AAAs) prevents growth arrest …

Expression of GPI-anchored T-cadherin (T-cad) on vascular smooth muscle cells (VSMC) is
elevated in vascular disorders such as atherosclerosis and restenosis which are associated …