The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that
are subdivided into several distinct families on a structural and biochemical basis. In …

1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …

The human genome expresses nine patatin-like phospholipase domain containing proteins
(PNPLA1–9). Members of this family share a protein domain discovered initially in patatin …

Adipose triglyceride lipase (ATGL) is rate-limiting for the initial step of triacylglycerol (TAG)
hydrolysis, generating diacylglycerol (DAG) and fatty acids. DAG exists in three …

The membranes of mammalian cells contain hundreds of different phospholipid species, a
variety of glycolipids and cholesterol. While the reasons for such compositional diversity are …

Abstract In essence,“phospholipase A 2”(PLA 2) means a group of enzymes that release
fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids …

Choline supplies methyl groups for regeneration of methionine and the methyl donor S-
adenosylmethionine in the liver. Here, we report that the catabolism of membrane …

Adipose triglyceride lipase (ATGL) is rate limiting in the mobilization of fatty acids from
cellular triglyceride stores. This central role in lipolysis marks ATGL as an interesting …

The release of fatty acids from membrane glycerolipids has been implicated in a variety of
cellular processes, but the enzymes involved and their regulation are poorly understood in …