The intertwined physics of active chemical reactions and phase separation

D Zwicker - Current Opinion in Colloid & Interface Science, 2022 - Elsevier
Phase separation is the thermodynamic process that explains how droplets form in
multicomponent fluids. These droplets can provide controlled compartments to localize …

Putting the squeeze on phase separation

C Fernández-Rico, T Sai, A Sicher, RW Style… - JACS Au, 2021 - ACS Publications
Phase separation is a ubiquitous process and finds applications in a variety of biological,
organic, and inorganic systems. Nature has evolved the ability to control phase separation to …

[HTML][HTML] Non-specific adhesive forces between filaments and membraneless organelles

TJ Böddeker, KA Rosowski, D Berchtold… - Nature physics, 2022 - nature.com
Many membraneless organelles are liquid-like domains that form inside the active,
viscoelastic environment of living cells through phase separation. To investigate the …

Morphogenesis and cell ordering in confined bacterial biofilms

Q Zhang, J Li, J Nijjer, H Lu, M Kothari… - Proceedings of the …, 2021 - National Acad Sciences
Biofilms are aggregates of bacterial cells surrounded by an extracellular matrix. Much
progress has been made in studying biofilm growth on solid substrates; however, little is …

Mechanical frustration of phase separation in the cell nucleus by chromatin

Y Zhang, DSW Lee, Y Meir, CP Brangwynne… - Physical review …, 2021 - APS
Liquid-liquid phase separation is a fundamental mechanism underlying subcellular
organization. Motivated by the striking observation that optogenetically generated droplets in …

Modeling elastically mediated liquid-liquid phase separation

X Wei, J Zhou, Y Wang, F Meng - Physical Review Letters, 2020 - APS
We propose a continuum theory of the liquid-liquid phase separation in an elastic network,
where phase-separated microscopic droplets rich in one fluid component can form as an …

Liquid demixing in elastic networks: Cavitation, permeation, or size selection?

P Ronceray, S Mao, A Košmrlj, MP Haataja - Europhysics Letters, 2022 - iopscience.iop.org
In cells, phase-separated liquid condensates interact mechanically with surrounding elastic
networks such as chromatin and cytoskeleton. By considering the trade-offs between elastic …

Cavitation controls droplet sizes in elastic media

E Vidal-Henriquez, D Zwicker - Proceedings of the National …, 2021 - National Acad Sciences
Biological cells use droplets to separate components and spatially control their interior.
Experiments demonstrate that the complex, crowded cellular environment affects the droplet …

Designing the morphology of separated phases in multicomponent liquid mixtures

S Mao, MS Chakraverti-Wuerthwein, H Gaudio… - Physical review …, 2020 - APS
Phase separation of multicomponent liquid mixtures plays an integral part in many
processes ranging from industry to cellular biology. In many cases the morphology of …

Heterogeneous elasticity drives ripening and controls bursting kinetics of transcriptional condensates

L Meng, S Mao, J Lin - … of the National Academy of Sciences, 2024 - National Acad Sciences
Many biomolecular condensates, including transcriptional condensates, are formed in
elastic mediums. In this work, we study the nonequilibrium condensate dynamics in a …