Characterizing the structures, interactions, and dynamics of molecules in their native liquid
state is a long-existing challenge in chemistry, molecular science, and biophysics with …

High-quality specimen preparation plays a crucial role in cryo-electron microscopy (cryo-
EM) structural analysis. In this study, we have developed a reliable and convenient …

When evaluating soft self-assembling materials for use in any application, the structural or
morphological characterisation is highly important. We know that the hierarchal molecular …

Air-water interface (AWI) interactions during cryo-electron microscopy (cryo-EM) sample
preparation cause significant sample loss, hindering structural biology research. Organisms …

Cryo-electron microscopy (cryo-EM) has been widely used to reveal the structures of
proteins at atomic resolution. One key challenge is that almost all proteins are predominantly …

Single-particle cryo-EM is widely used to determine enzyme-nucleosome complex
structures. However, cryo-EM sample preparation remains challenging and inconsistent due …

Cryogenic electron microscopy (cryoEM) has emerged as a powerful technique for probing
the atomic structure of macromolecular complexes. Sample preparation for cryoEM requires …

Specimen preparation is a critical but challenging step in high-resolution cryogenic electron
microscopy (cryo-EM) structural analysis of macromolecules. In the past decade, graphene …

Lipid membranes and proteins, which are part of us throughout our lives, have been studied
for decades. However, every year, new discoveries show how little we know about them. In a …

Sample preparation can present a significant hurdle within single particle cryo-electron
microscopy (cryoEM), resulting in issues with reproducibility, data quality or an inability to …