G-protein-coupled receptors (GPCRs) and G-proteins have a range of roles in many
physiological and pathological processes and are among the most studied signaling …

Many intracellular pathogens cause disease by subverting macrophage innate immune
defense mechanisms. Intracellular pathogens actively avoid delivery to or directly target …

Regulator of G protein signaling 14 (RGS14) is a multifunctional scaffolding protein that
integrates heterotrimeric G protein and H-Ras signaling pathways. RGS14 possesses an …

Polycystic kidney diseases are the most common genetic diseases that affect the kidney.
There remains a paucity of information regarding mechanisms by which G proteins are …

Activator of G protein signaling (AGS)-3 plays functional roles in cell division, synaptic
plasticity, addictive behavior, and neuronal development. As part of a broad effort to define …

G protein–coupled receptors (GPCRs) transduce their signals through trimeric G proteins,
inducing guanine nucleotide exchange on their Gα-subunits; the resulting Gα-GTP transmits …

Beyond the core triad of receptor, Gαβγ and effector, there are multiple accessory proteins
that provide alternative modes of signal input and regulatory adaptability to G‐protein …

G-protein signaling modulators (GPSM) play diverse functional roles through their
interaction with G-protein subunits. AGS3 (GPSM1) contains four G-protein regulatory motifs …

Group II activators of G-protein signaling (AGS) serve as binding partners for Gα i/o/t via one
or more G-protein regulatory (GPR) motifs. GPR-Gα signaling modules may be differentially …

Learning and memory are encoded within the brain as biochemical and physical changes at
synapses that alter synaptic transmission, a process known as synaptic plasticity. Although …