Brain Derived Neurotrophic Factor (BDNF) is a key molecule involved in plastic changes
related to learning and memory. The expression of BDNF is highly regulated, and can lead …

The complexity of human DNA has been affected by aerobic metabolism, including
endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an …

This article reviews findings up to the end of 1997 about the inducible transcription factors
(ITFs) c-Jun, JunB, JunD, c-Fos, FosB, Fra-1, Fra-2, Krox-20 (Egr-2) and Krox-24 (NGFI-A …

Contrary to previous dogmas, it is now well established that brain cells can produce
cytokines and chemokines, and can express adhesion molecules that enable an in situ …

Alzheimer's disease may be due to a deficiency in neurotrophin protein or receptor
expression. Consistent with this hypothesis, a reduction in BDNF mRNA expression has …

Background and Purpose—Pretreatment with intraventricular brain-derived neurotrophic
factor (BDNF) reduces ischemic damage after focal cerebral ischemia. In this experiment we …

Though the ischemic penumbra has been classically described on the basis of blood flow
and physiologic parameters, a variety of ischemic penumbras can be described in molecular …

Bcl‐2 protects against both apoptotic and necrotic death induced by several cerebral insults.
We and others have previously demonstrated that defective herpes simplex virus vectors …

Background and Purpose—A short duration of ischemia (ie, ischemic preconditioning [PC])
can provide significant brain protection to subsequent ischemic events (ie, ischemic …

Brain-derived neurotrophic factor (BDNF), acting through the high-affinity receptor tyrosine
kinase (TrkB), is widely distributed throughout the central nervous system and displays in …