Niacin (also known as “vitamin B3” or “vitamin PP”) includes two vitamers (nicotinic acid and
nicotinamide) giving rise to the coenzymatic forms nicotinamide adenine dinucleotide (NAD) …

Background The abundance of energy metabolites is intimately interconnected with the
activity of chromatin-modifying enzymes in order to guarantee the finely tuned modulation of …

Cancers disrupt host homeostasis in various manners but the identity of host factors
underlying such disruption remains largely unknown. Here we show that nicotinamide-N …

Metabolic routing of nicotinamide (NAM) to NAD+ or 1-methylnicotinamide (MeNAM) has
impacts on human health and aging. NAM is imported by cells or liberated from NAD+. The …

Homocysteine (Hcy) is one of the independent risk factors of cardiovascular disease.
Sodium tanshinone IIA sulfonate (STS) is a hydrophilic derivate of tanshinone IIA which is …

Abstract Polycystic Ovary Syndrome (PCOS), as a common endocrine disorder is
accompanied by hyperandrogenism, insulin resistance, ovulation problems, and infertility …

Macroautophagy is a “cell cleansing” process that rids cells of protein aggregates and
damaged organelles that may contribute to disease pathogenesis and the dysfunctions …

Dietary vitamin B3 components, such as nicotinamide and nicotinic acid, are precursors to
the ubiquitous redox cofactor nicotinamide adenine dinucleotide (NAD+). NAD+ levels are …

Objective. To explore the effects of N1‐methylnicotinamide (MNAM) on insulin resistance
and glucose metabolism in obese type 2 diabetes mellitus (T2DM) mice and regulatory …

Abstract Nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1) is required for
nuclear nicotinamide adenine mononucleotide (NAD+) biosynthesis in all nucleated cells …