The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

Neutrophils are the most abundant, short lived, and terminally differentiated leukocytes with
distinct tiers of arsenals to counter pathogens. Neutrophils were traditionally considered …

Airway neutrophilia is a common feature of many chronic inflammatory lung diseases and is
associated with disease progression, often regardless of the initiating cause. Neutrophils …

Exaggerated release of neutrophil extracellular traps (NETs) along with decreased NET
clearance and inability to remove apoptotic cells (efferocytosis) may contribute to sustained …

Cellular responses to stress can be defined by the overwhelming number of changes that
cells go through upon contact with and stressful conditions such as infection and …

Background Metformin, the most widely administered diabetes drug, has been proposed as
a candidate adjunctive host-directed therapy for tuberculosis, but little is known about its …

The spread of human immunodeficiency virus (HIV) infection within Africa led to marked
increases in numbers of cases of tuberculosis (TB), and although the epidemic peaked in …

Endothelial barrier function is an essential and tightly regulated process that ensures proper
compartmentalization of the vascular and interstitial space, while allowing for the diffusive …

ABSTRACT T cells must tightly regulate their metabolic processes to cope with varying
bioenergetic demands depending on their state of differentiation. The metabolic sensor …

In Legionella pneumophila infection, macrophages play a critical role in the host defense
response. Metformin, an oral drug for type 2 diabetes, is attracting attention as a new …