HLA-G: at the interface of maternal–fetal tolerance
During pregnancy, semiallogeneic fetal extravillous trophoblasts (EVT) invade the uterine
mucosa without being rejected by the maternal immune system. Several mechanisms were …
mucosa without being rejected by the maternal immune system. Several mechanisms were …
Tissue-Resident Memory CD8+ T Cells: From Phenotype to Function
DJ Topham, EC Reilly - Frontiers in immunology, 2018 - frontiersin.org
Tissue-resident memory CD8+ T cells are an important first line of defense from infection in
peripheral non-lymphoid tissues, such as the mucosal tissues of the respiratory, digestive …
peripheral non-lymphoid tissues, such as the mucosal tissues of the respiratory, digestive …
Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
L Weinhard, G Di Bartolomei, G Bolasco… - Nature …, 2018 - nature.com
Microglia are highly motile glial cells that are proposed to mediate synaptic pruning during
neuronal circuit formation. Disruption of signaling between microglia and neurons leads to …
neuronal circuit formation. Disruption of signaling between microglia and neurons leads to …
The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages
Tissue macrophages (Mϕ) are essential effector cells in rheumatoid arthritis (RA),
contributing to autoimmune tissue inflammation through diverse effector functions. Their …
contributing to autoimmune tissue inflammation through diverse effector functions. Their …
Proinflammatory CD20+ T cells contribute to CNS-directed autoimmunity
J Ochs, N Nissimov, S Torke, M Freier… - Science translational …, 2022 - science.org
The origin and function of CD20+ T cells are poorly understood. Here, we characterized
CD20+ T cells in mice and humans and investigated how they are affected by anti-CD20 …
CD20+ T cells in mice and humans and investigated how they are affected by anti-CD20 …
Appropriation of GPIbα from platelet-derived extracellular vesicles supports monocyte recruitment in systemic inflammation
M Chimen, A Evryviadou, CL Box, MJ Harrison… - …, 2019 - pmc.ncbi.nlm.nih.gov
Interactions between platelets, leukocytes and the vessel wall provide alternative
pathological routes of thrombo-inflammatory leukocyte recruitment. We found that when …
pathological routes of thrombo-inflammatory leukocyte recruitment. We found that when …
Antigen presentation by MHC-dressed cells
M Nakayama - Frontiers in immunology, 2015 - frontiersin.org
Professional antigen-presenting cells (APCs) such as conventional dendritic cells (DCs)
process protein antigens to MHC-bound peptides and then present the peptide–MHC …
process protein antigens to MHC-bound peptides and then present the peptide–MHC …
Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis
D Trzupek, M Dunstan, AJ Cutler, M Lee, L Godfrey… - Genome medicine, 2020 - Springer
Background Traditionally, the transcriptomic and proteomic characterisation of CD4+ T cells
at the single-cell level has been performed by two largely exclusive types of technologies …
at the single-cell level has been performed by two largely exclusive types of technologies …
Neutrophils kill the parasite Trichomonas vaginalis using trogocytosis
F Mercer, SH Ng, TM Brown, G Boatman… - PLoS biology, 2018 - journals.plos.org
T. vaginalis, a human-infective parasite, causes the most common nonviral sexually
transmitted infection (STI) worldwide and contributes to adverse inflammatory disorders. The …
transmitted infection (STI) worldwide and contributes to adverse inflammatory disorders. The …
Lymphocytes and trogocytosis-mediated signaling
Trogocytosis is the intercellular transfer of membrane and membrane-associated molecules.
This underappreciated process has been described in a variety of biological settings …
This underappreciated process has been described in a variety of biological settings …