[HTML][HTML] Consensus Guidance for Monitoring Individuals With Islet Autoantibody–Positive Pre-Stage 3 Type 1 Diabetes

M Phillip, P Achenbach, A Addala… - Diabetes …, 2024 - diabetesjournals.org
Given the proven benefits of screening to reduce diabetic ketoacidosis (DKA) likelihood at
the time of stage 3 type 1 diabetes diagnosis, and emerging availability of therapy to delay …

Lipid peroxidation linking diabetes and cancer: the importance of 4-hydroxynonenal

M Jaganjac, N Zarkovic - Antioxidants & redox signaling, 2022 - liebertpub.com
Significance: It is commonly believed that diabetes mellitus may be associated with cancer.
Hence, diabetic patients are at higher risk for hepatocellular carcinoma, pancreatic cancer …

[HTML][HTML] Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes

S Lamichhane, P Sen, AM Dickens, MA Alves… - Cell Reports …, 2022 - cell.com
The gut microbiota is crucial in the regulation of bile acid (BA) metabolism. However, not
much is known about the regulation of BAs during progression to type 1 diabetes (T1D) …

[HTML][HTML] Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection

J Lin, E Moradi, K Salenius, S Lehtipuro… - Nature …, 2023 - nature.com
Although the genetic basis and pathogenesis of type 1 diabetes have been studied
extensively, how host responses to environmental factors might contribute to autoantibody …

An overview of metabolomics data analysis: current tools and future perspectives

S Lamichhane, P Sen, AM Dickens… - Comprehensive …, 2018 - Elsevier
Metabolomics is a study of small molecules in the body and the associated metabolic
pathways and is considered to provide a close link between organism's genotype and …

[HTML][HTML] Systems biology approaches to study lipidomes in health and disease

MA Alves, S Lamichhane, A Dickens… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Lipids have many important biological roles, such as energy storage sources, structural
components of plasma membranes and as intermediates in metabolic and signaling …

[HTML][HTML] Plasma protein biomarkers predict the development of persistent autoantibodies and type 1 diabetes 6 months prior to the onset of autoimmunity

ES Nakayasu, LM Bramer, C Ansong… - Cell Reports …, 2023 - cell.com
Summary Type 1 diabetes (T1D) results from autoimmune destruction of β cells. Insufficient
availability of biomarkers represents a significant gap in understanding the disease cause …

Circulating free fatty acid and phospholipid signature predicts early rapid kidney function decline in patients with type 1 diabetes

F Afshinnia, TM Rajendiran, C He, J Byun… - Diabetes …, 2021 - Am Diabetes Assoc
OBJECTIVES Patients with type 1 diabetes (T1D) exhibit modest lipid abnormalities as
measured by traditional metrics. This study aimed to identify lipidomic predictors of rapid …

Metabolomics of type 1 and type 2 diabetes: insights into risk prediction and mechanisms

DG Izundegui, M Nayor - Current diabetes reports, 2022 - Springer
Abstract Purpose of Review Metabolomics enables rapid interrogation of widespread
metabolic processes making it well suited for studying diabetes. Here, we review the current …

[HTML][HTML] Lipidomes in health and disease: Analytical strategies and considerations

F Wei, S Lamichhane, M Orešič… - TrAC Trends in Analytical …, 2019 - Elsevier
Lipidomics is a rapidly-growing field which focuses on global characterization of lipids at
molecular and systems levels. As small changes in the concentrations of lipids may have …