Role of RUNX1 in hematological malignancies
R Sood, Y Kamikubo, P Liu - … Journal of the American Society of …, 2017 - ashpublications.org
RUNX1 is a member of the core-binding factor family of transcription factors and is
indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is …
indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is …
MicroRNA control of bone formation and homeostasis
JB Lian, GS Stein, AJ Van Wijnen, JL Stein… - Nature Reviews …, 2012 - nature.com
MicroRNAs (miRNAs) repress cellular protein levels to provide a sophisticated parameter of
gene regulation that coordinates a broad spectrum of biological processes. Bone …
gene regulation that coordinates a broad spectrum of biological processes. Bone …
DUSPs, to MAP kinases and beyond
CY Huang, TH Tan - Cell & bioscience, 2012 - Springer
Phosphatases are important regulators of intracellular signaling events, and their functions
have been implicated in many biological processes. Dual-specificity phosphatases …
have been implicated in many biological processes. Dual-specificity phosphatases …
A network connecting Runx2, SATB2, and the miR-23a∼ 27a∼ 24-2 cluster regulates the osteoblast differentiation program
Induced osteogenesis includes a program of microRNAs (miRs) to repress the translation of
genes that act as inhibitors of bone formation. How expression of bone-related miRs is …
genes that act as inhibitors of bone formation. How expression of bone-related miRs is …
TET2 Mutations Improve the New European LeukemiaNet Risk Classification of Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study
Purpose To determine the frequency of TET2 mutations, their associations with clinical and
molecular characteristics and outcome, and the associated gene-and microRNA-expression …
molecular characteristics and outcome, and the associated gene-and microRNA-expression …
Cooperative and individualistic functions of the microRNAs in the miR-23a~ 27a~ 24-2 cluster and its implication in human diseases
The small RNA molecules of about 19-22 nucleotides in length, aptly called microRNAs,
perform the task of gene regulation in the cell. Interestingly, till the early nineties very little …
perform the task of gene regulation in the cell. Interestingly, till the early nineties very little …
[PDF][PDF] Circulating microRNAs are elevated in plasma from severe preeclamptic pregnancies
L Wu, HH Zhou, HY Lin, JG Qi, C Zhu, ZY Gao… - 2012 - Citeseer
Until recently, the molecular pathogenesis of preeclampsia (PE) remained largely unknown.
Reports have shown that circulating microRNAs (miRNAs) are promising novel biomarkers …
Reports have shown that circulating microRNAs (miRNAs) are promising novel biomarkers …
[HTML][HTML] MiRNAs: dynamic regulators of immune cell functions in inflammation and cancer
S Hirschberger, LC Hinske, S Kreth - Cancer letters, 2018 - Elsevier
MicroRNAs (miRNAs), small noncoding RNA molecules, have emerged as important
regulators of almost all cellular processes. By binding to specific sequence motifs within the …
regulators of almost all cellular processes. By binding to specific sequence motifs within the …
Regulatory roles of MAPK phosphatases in cancer
HB Low, Y Zhang - Immune network, 2016 - synapse.koreamed.org
The mitogen-activated protein kinases (MAPKs) are key regulators of cell growth and
survival in physiological and pathological processes. Aberrant MAPK signaling plays a …
survival in physiological and pathological processes. Aberrant MAPK signaling plays a …
Depletion of RUNX1/ETO in t (8; 21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding
A Ptasinska, SA Assi, D Mannari, SR James… - Leukemia, 2012 - nature.com
Abstract The t (8; 21) translocation fuses the DNA-binding domain of the hematopoietic
master regulator RUNX1 to the ETO protein. The resultant RUNX1/ETO fusion protein is a …
master regulator RUNX1 to the ETO protein. The resultant RUNX1/ETO fusion protein is a …