Flaviviruses consist of significant human pathogens responsible for hundreds of millions of
infections each year. Their antigenic relationships generate immune responses that are …

DENV is a major public health problem worldwide, thus underlining the overall significance
of the proposed Program. The four dengue virus (DENV) serotypes (1–4) cause the most …

Endothelial dysfunction leading to vascular leak is the hallmark of severe dengue. Vascular
leak typically becomes clinically evident 3–6 days after the onset of illness, which is known …

The spread of dengue virus throughout the tropics represents a major, rapidly growing
public health problem with an estimated 2· 5 billion people at risk of dengue fever and the …

Serotype-cross-reactive memory T cells responding to secondary dengue virus (DENV)
infection are thought to contribute to disease. However, epitope-specific T cell responses …

Background Genetic variation and rapid evolution are hallmarks of RNA viruses, the result of
high mutation rates in RNA replication and selection of mutants that enhance viral …

The tendency to use the terms homology, similarity, and identity interchangeably persists in
comparative biology. When translated to immunology, overlapping the concepts of …

Immune activation is a feature of dengue hemorrhagic fever (DHF) and CD8+ T cell
responses in particular have been suggested as having a role in the vasculopathy that …

Cross‐reactive memory T cells induced by primary infection with one of the four serotypes of
dengue virus (DENV) are hypothesized to have an immunopathological function in …

The precise immunological role played by CD4+ T cells in retroviral infections is poorly
defined. Here, we describe a new function of these cells, the elimination of retrovirus …