SRC homology 3 (SH3) domains are fundamental modules that enable the assembly of
protein complexes through physical interactions with a pool of proline-rich/noncanonical …

Myosin-I molecular motors are proposed to play various cellular roles related to membrane
dynamics and trafficking. In this Cell Science at a Glance article and the accompanying …

Glomerular hypertension is an important factor exacerbating glomerular diseases to end-
stage renal diseases because, ultimately, it results in glomerular sclerosis (especially in …

The actin cytoskeleton, which regulates cell polarity, adhesion, and migration, can influence
cancer progression, including initial acquisition of malignant properties by normal cells …

The architectural integrity of tissues requires complex interactions, both between cells and
between cells and the extracellular matrix. Fundamental to cell and tissue homeostasis are …

In the past 20 years, multiple genetic mutations have been identified in patients with
congenital nephrotic syndrome (CNS) and both familial and sporadic focal segmental …

Metastasis of breast cancer cells to distant tissue sites is responsible for the majority of
deaths associated with breast cancer. Previously we have examined the role of class I …

Severe defects in the glomerular filtration barrier result in nephrotic syndrome, which is
characterized by massive proteinuria. The podocyte, a specialized epithelial cell with …

Despite advancing therapies, thousands of women die every year of breast cancer. Myosins,
actin-dependent molecular motors, are likely to contribute to tumor formation and metastasis …

Long-tailed unconventional class I myosin, Myosin 1E (MYO1E) and Myosin 1F (MYO1F) are
motor proteins that use chemical energy from the hydrolysis of adenosine triphosphate …