[HTML][HTML] Oncolytic adenovirus: strategies and insights for vector design and immuno-oncolytic applications

H Uusi-Kerttula, S Hulin-Curtis, J Davies, AL Parker - Viruses, 2015 - mdpi.com
Adenoviruses (Ad) are commonly used both experimentally and clinically, including
oncolytic virotherapy applications. In the clinical area, efficacy is frequently hampered by the …

[HTML][HTML] Expanding the spectrum of adenoviral vectors for cancer therapy

J Gao, W Zhang, A Ehrhardt - Cancers, 2020 - mdpi.com
Adenoviral vectors (AdVs) have attracted much attention in the fields of vaccine
development and treatment for diseases such as genetic disorders and cancer. In this …

[HTML][HTML] Boosting CAR T-cell responses in lymphoma by simultaneous targeting of CD40/4-1BB using oncolytic viral gene therapy

J Wenthe, S Naseri, A Labani-Motlagh… - Cancer Immunology …, 2021 - Springer
Pretreatment of B-cell lymphoma patients with immunostimulatory gene therapy using armed
oncolytic viruses may prime tumor lesions for subsequent chimeric antigen receptor (CAR) T …

Cryo-EM structure of human adenovirus D26 reveals the conservation of structural organization among human adenoviruses

X Yu, D Veesler, MG Campbell, ME Barry… - Science …, 2017 - science.org
Human adenoviruses (HAdVs) cause acute respiratory, ocular, and gastroenteric diseases
and are also frequently used as gene and vaccine delivery vectors. Unlike the archetype …

[PDF][PDF] Interactomics: dozens of viruses, co-evolving with humans, including the influenza A virus, may actively distort human aging

J Teulière, C Bernard, H Bonnefous… - Molecular biology …, 2023 - academic.oup.com
Some viruses (eg, human immunodeficiency virus 1 and severe acute respiratory syndrome
coronavirus 2) have been experimentally proposed to accelerate features of human aging …

Retargeting adenoviruses for therapeutic applications and vaccines

MA Barry, JD Rubin, SC Lu - FEBS letters, 2020 - Wiley Online Library
Adenoviruses (Ads) are robust vectors for therapeutic applications and vaccines, but their
use can be limited by differences in their in vitro and in vivo pharmacologies. This review …

Ex Vivo and In Vivo CD46 Receptor Utilization by Species D Human Adenovirus Serotype 26 (HAdV26)

JR Hemsath, AM Liaci, JD Rubin, BJ Parrett… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT Human adenovirus serotype 26 (Ad26) is used as a gene-based vaccine
against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and HIV-1 …

Tutorial: design, production and testing of oncolytic viruses for cancer immunotherapy

S Gujar, JG Pol, V Kumar, M Lizarralde-Guerrero… - Nature …, 2024 - nature.com
Oncolytic viruses (OVs) represent a novel class of cancer immunotherapy agents that
preferentially infect and kill cancer cells and promote protective antitumor immunity …

[HTML][HTML] Oncolytic viruses as a promising therapeutic strategy for hematological malignancies

C Yang, N Hua, S Xie, Y Wu, L Zhu, S Wang… - Biomedicine & …, 2021 - Elsevier
The incidence of hematological malignancies such as multiple myeloma, leukemia, and
lymphoma has increased over time. Although bone marrow transplantation, immunotherapy …

Development of gene therapy for blood disorders: an update

AW Nienhuis - Blood, The Journal of the American Society of …, 2013 - ashpublications.org
This review addresses the current status of gene therapy for immunodeficiencies, chronic
granulomatous disease, suicide gene therapy for graft-versus-host disease, viral infections …