Drug absorption from the gastrointestinal (GI) tract is a highly complex process dependent
upon numerous factors including the physicochemical properties of the drug, characteristics …

UDP-glucuronosyltransferase (UGT) and esterases are recognized as the most important
non-P450 enzymes because of their high contribution to drug metabolism. UGTs catalyze …

Glucuronidation mediated by UDP-glucuronosyltransferases (UGTs) is a significant
metabolic pathway that facilitates efficient elimination of numerous endobiotics and …

Transition metals have been an indispensable component of modern catalysis and among
these palladium is the top‐ranked choice of chemists as a catalyst. After the several …

Scientific achievements in the last two decades have revolutionized the treatment and
prevention of breast cancer. This is mainly because of targeted therapies and a better …

In vitro covalent binding assessments of drugs have been useful in providing retrospective
insights into the association between drug metabolism and a resulting toxicological …

The metabolism of tamoxifen is being redefined in the light of several important
pharmacological observations. Recent studies have identified 4-hydroxy N …

The uridine diphosphoglucuronosyltransferases (UGTs) belong to a superfamily of enzymes
that catalyse the glucuronidation of numerous endobiotics and xenobiotics. Several human …

Baicalin was extensively researched for utility in a number of therapeutic areas owing to its
anti-inflammatory, anti-oxidant, anti-bacterial, and anti-cancer properties. A number of …

Intestinal metabolism can limit oral bioavailability of drugs and increase the risk of drug
interactions. It is therefore important to be able to predict and quantify it in drug discovery …