Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent
kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as …

Cyclin-dependent kinases (Cdks) are the catalytic subunits of a family of mammalian
heterodimeric serine/threonine kinases that have been implicated in the control of cell-cycle …

The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-
dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates …

Entry into, progression through, and exit from the G1 phase of the mammalian cell cycle in
response to extracellular mitogenic cues are presumed to be governed by cyclin-dependent …

The regulation and function of cyclin‐dependent kinase 6 (CDK6)‐and cyclin‐dependent
kinase 4 (CDK4)‐cyclin complexes are commonly altered with enhanced kinase activity …

The corpus luteum (CL) is one of the few endocrine glands that forms from the remains of
another organ and whose function and survival are limited in scope and time. The CL is the …

Cdk4 and Cdk6 are thought to be essential for initiation of the cell cycle in response to
mitogenic stimuli. Previous studies have shown that Cdk4 is dispensable for proliferation in …

Pituitary adenomas may hypersecrete hormones (including prolactin, growth hormone and
adrenocorticotropic hormone, and rarely follicle-stimulating hormone, luteinizing hormone or …

The anterior pituitary gland integrates the repertoire of hormonal signals controlling thyroid,
adrenal, reproductive, and growth functions. The gland responds to complex central and …

The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-
dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates …