Estrogen effects on cognitive and synaptic health over the lifecourse

Y Hara, EM Waters, BS McEwen… - Physiological …, 2015 - journals.physiology.org
Estrogen facilitates higher cognitive functions by exerting effects on brain regions such as
the prefrontal cortex and hippocampus. Estrogen induces spinogenesis and synaptogenesis …

Dendritic spines: the locus of structural and functional plasticity

C Sala, M Segal - Physiological reviews, 2014 - journals.physiology.org
The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …

[HTML][HTML] Structural plasticity of the hippocampus in response to estrogens in female rodents

PAS Sheppard, E Choleris, LAM Galea - Molecular brain, 2019 - Springer
It is well established that estrogens affect neuroplasticity in a number of brain regions. In
particular, estrogens modulate and mediate spine and synapse formation as well as …

Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny

B Jeong, JY Baek, J Koo, S Park, YK Ryu… - Journal of Hazardous …, 2022 - Elsevier
As global plastic production continues to grow, microplastics released from a massive
quantity of plastic wastes have become a critical environmental concern. These microplastic …

Sex differences in the brain: Implications for behavioral and biomedical research

E Choleris, LAM Galea, F Sohrabji, KM Frick - … & Biobehavioral Reviews, 2018 - Elsevier
Biological differences between males and females are found at multiple levels. However,
females have too often been under-represented in behavioral neuroscience research, which …

Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents

KM Frick, J Kim, JJ Tuscher, AM Fortress - Learning & Memory, 2015 - learnmem.cshlp.org
Ample evidence has demonstrated that sex steroid hormones, such as the potent estrogen
17β-estradiol (E2), affect hippocampal morphology, plasticity, and memory in male and …

Dendritic spine changes associated with normal aging

DL Dickstein, CM Weaver, JI Luebke, PR Hof - Neuroscience, 2013 - Elsevier
Given the rapid rate of population aging and the increased incidence of cognitive decline
and neurodegenerative diseases with advanced age, it is important to ascertain the …

Sex differences in hippocampal function

WA Koss, KM Frick - Journal of neuroscience research, 2017 - Wiley Online Library
Sex differences in the function of the hippocampus have been observed in numerous
mammalian species. However, the magnitude, extent, and specificity of these differences are …

Why estrogens matter for behavior and brain health

LAM Galea, KM Frick, E Hampson, F Sohrabji… - Neuroscience & …, 2017 - Elsevier
Abstract The National Institutes of Health (NIH) has required the inclusion of women in
clinical studies since 1993, which has enhanced our understanding of how biological sex …

Uncovering the mechanisms of estrogen effects on hippocampal function

JL Spencer, EM Waters, RD Romeo, GE Wood… - Frontiers in …, 2008 - Elsevier
Estrogens have direct effects on the brain areas controlling cognition. One of the most
studied of these regions is the dorsal hippocampal formation, which governs the formation of …