[HTML][HTML] IgA: structure, function, and developability

P de Sousa-Pereira, JM Woof - Antibodies, 2019 - mdpi.com
Immunoglobulin A (IgA) plays a key role in defending mucosal surfaces against attack by
infectious microorganisms. Such sites present a major site of susceptibility due to their vast …

[HTML][HTML] IgA and FcαRI: pathological roles and therapeutic opportunities

A Breedveld, M Van Egmond - Frontiers in immunology, 2019 - frontiersin.org
Immunoglobulin A (IgA) is the most abundant antibody class present at mucosal surfaces.
The production of IgA exceeds the production of all other antibodies combined, supporting …

IgA dominates the early neutralizing antibody response to SARS-CoV-2

D Sterlin, A Mathian, M Miyara, A Mohr… - Science translational …, 2021 - science.org
Humoral immune responses are typically characterized by primary IgM antibody responses
followed by secondary antibody responses associated with immune memory and composed …

Immune response of neonates born to mothers infected with SARS-CoV-2

MG Conti, S Terreri, EP Mortari, C Albano… - JAMA Network …, 2021 - jamanetwork.com
Importance Although several studies have provided information on short-term clinical
outcomes in children with perinatal exposure to SARS-CoV-2, data on the immune response …

[HTML][HTML] Streptococcus pneumoniae colonization associates with impaired adaptive immune responses against SARS-CoV-2

E Mitsi, J Reiné, BC Urban, C Solórzano… - The Journal of …, 2022 - Am Soc Clin Investig
Background Although recent epidemiological data suggest that pneumococci may contribute
to the risk of SARS-CoV-2 disease, cases of coinfection with Streptococcus pneumoniae in …

When therapeutic IgA antibodies might come of age

D Sterlin, G Gorochov - Pharmacology, 2021 - karger.com
Background: Extensive efforts have been made in optimizing monoclonal immunoglobulin
(Ig) G antibodies for use in clinical practice. Accumulating evidence suggests that IgA or anti …

[HTML][HTML] Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller

V Lorin, I Fernández, G Masse-Ranson… - Journal of Experimental …, 2022 - rupress.org
Decrypting the B cell ontogeny of HIV-1 broadly neutralizing antibodies (bNAbs) is
paramount for vaccine design. Here, we characterized IgA and IgG bNAbs of three distinct B …

[HTML][HTML] Immunity in SARS-CoV-2 Infection: Clarity or Mystery? A Broader Perspective in the Third Year of a Worldwide Pandemic

K Kapten, K Orczyk, E Smolewska - Archivum Immunologiae et Therapiae …, 2023 - Springer
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its mechanisms have
been thoroughly studied by researchers all over the world with the hope of finding answers …

Immune response to HIV

M Perreau, Y Levy, G Pantaleo - Current Opinion in HIV and AIDS, 2013 - journals.lww.com
In the present review, we shall discuss the different components of the HIV-specific immune
response elicited by the infection, the kinetics of these responses during primary infection …

Induction of mucosal and systemic antibody and T-cell responses following prime–boost immunization with novel adjuvanted human immunodeficiency virus-1 …

AD Cristillo, MG Ferrari, L Hudacik… - Journal of general …, 2011 - microbiologyresearch.org
As sexual transmission of human immunodeficiency virus-1 (HIV-1) occurs via the mucosa,
an ideal HIV-1 vaccine should induce both mucosal and systemic immunity. We therefore …