Since human embryonic stem cells were first differentiated to beating cardiomyocytes a
decade ago, interest in their potential applications has increased exponentially. This has …

The potential to generate virtually any differentiated cell type from embryonic stem cells
(ESCs) offers the possibility to establish new models of mammalian development and to …

Cardiomyocytes derived from human embryonic stem (hES) cells potentially offer large
numbers of cells to facilitate repair of the infarcted heart. However, this approach has been …

The discovery of mouse embryonic stem (ES) cells> 20 years ago represented a major
advance in biology and experimental medicine, as it enabled the routine manipulation of the …

Cell-based cardiac repair offers the promise of rebuilding the injured heart from its
component parts. Work began with committed cells such as skeletal myoblasts, but recently …

When cultured in suspension without antidifferentiation factors, embryonic stem (ES) cells
spontaneously differentiate and form three-dimensional multicellular aggregates called …

HL-1 cells are currently the only cardiomyocyte cell line available that continuously divides
and spontaneously contracts while maintaining a differentiated cardiac phenotype …

Human embryonic stem cells (hESCs) offer the opportunity to replenish cells lost in the
postinfarct heart. We explored whether human myocardium could be generated in rat hearts …

Substantial evidence indicates that cell transplantation can improve function of the infarcted
heart. A surprisingly wide range of non-myogenic cell types improves ventricular function …

Many cell populations, derived from both adult tissues and embryonic stem cells, show
promise for the treatment of a variety of diseases. Although the major effort in stem cell …