Ventricular arrhythmias and the His–Purkinje system
M Haissaguerre, E Vigmond, B Stuyvers… - Nature Reviews …, 2016 - nature.com
Ventricular arrhythmias are a major cause of sudden death, which accounts for
approximately half of cardiac mortality. The His–Purkinje system is composed of specialized …
approximately half of cardiac mortality. The His–Purkinje system is composed of specialized …
European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) …
JC Nielsen, YJ Lin, MJ de Oliveira Figueiredo… - Ep …, 2020 - academic.oup.com
Patients with cardiac diseases or conditions with high risk of developing cardiac diseases
undergo risk assessment by cardiologists, primary care physicians, and scientists based on …
undergo risk assessment by cardiologists, primary care physicians, and scientists based on …
Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology
OJ Britton, A Bueno-Orovio… - Proceedings of the …, 2013 - National Acad Sciences
Cellular and ionic causes of variability in the electrophysiological activity of hearts from
individuals of the same species are unknown. However, improved understanding of this …
individuals of the same species are unknown. However, improved understanding of this …
[PDF][PDF] So little source, so much sink: requirements for afterdepolarizations to propagate in tissue
How early (EADs) and delayed afterdepolarizations (DADs) overcome electrotonic source-
sink mismatches in tissue to trigger premature ventricular complexes remains incompletely …
sink mismatches in tissue to trigger premature ventricular complexes remains incompletely …
Alternans and arrhythmias: from cell to heart
The goal of systems biology is to relate events at the molecular level to more integrated
scales from organelle to cell, tissue, and living organism. Here, we review how normal and …
scales from organelle to cell, tissue, and living organism. Here, we review how normal and …
Mechanisms of ventricular arrhythmias: from molecular fluctuations to electrical turbulence
Ventricular arrhythmias have complex causes and mechanisms. Despite extensive
investigation involving many clinical, experimental, and computational studies, effective …
investigation involving many clinical, experimental, and computational studies, effective …
Local β-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia
Rationale: β-Adrenergic receptor stimulation produces sarcoplasmic reticulum Ca2+
overload and delayed afterdepolarizations in isolated ventricular myocytes. How delayed …
overload and delayed afterdepolarizations in isolated ventricular myocytes. How delayed …
[HTML][HTML] Calcium handling defects and cardiac arrhythmia syndromes
Calcium ions (Ca 2+) play a major role in the cardiac excitation-contraction coupling.
Intracellular Ca 2+ concentration increases during systole and falls in diastole thereby …
Intracellular Ca 2+ concentration increases during systole and falls in diastole thereby …
The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with
substantial morbidity and mortality. It causes profound changes in sarcoplasmic reticulum …
substantial morbidity and mortality. It causes profound changes in sarcoplasmic reticulum …
[PDF][PDF] Calcium-voltage coupling in the genesis of early and delayed afterdepolarizations in cardiac myocytes
Early afterdepolarizations (EADs) and delayed afterdepolarizations (DADs) are voltage
oscillations known to cause cardiac arrhythmias. EADs are mainly driven by voltage …
oscillations known to cause cardiac arrhythmias. EADs are mainly driven by voltage …