Sepsis often is characterized by an acute brain dysfunction, which is associated with
increased morbidity and mortality. Its pathophysiology is highly complex, resulting from both …

Background Postoperative delirium is a common preventable complication experienced by
older adults undergoing elective surgery. In this systematic review and meta-analysis, we …

Objective: To update and expand the 2013 Clinical Practice Guidelines for the Management
of Pain, Agitation, and Delirium in Adult Patients in the ICU. Design:

The co-morbidity between smoking and mood disorders is striking. Preclinical and clinical
studies of nicotinic effects on mood, anxiety, aggression, and related behaviors, such as …

Purpose Our study investigated the relationships between the prevalence of depressive
symptoms and education levels in those aged≥ 20 years. Methods A total of 34,102 …

Introduction Optimal management of sedation, analgesia and delirium offers comfort and
security for the critical care patient, allows support measures to be applied more easily and …

Traumatic brain injury (TBI) can initiate a very complex disease of the central nervous
system (CNS), starting with the primary pathology of the inciting trauma and subsequent …

Introducción El óptimo manejo de la sedación, analgesia y delirium ofrece al paciente crítico
comodidad y seguridad, facilita el buen desarrollo de medidas de soporte y manejo integral …

Delirium is defined by a fluctuating level of attentiveness and has been associated with
increased ICU mortality and poor cognitive outcomes in both general ICU and neurocritical …

Objective: To evaluate the incidence of agitation in the first 7 days after intensive care unit
admission, its risk factors and its associations with clinical outcomes. Methods: This single …