Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disease that is of high importance to the
neuroscience world, yet the complex pathogenicity is not fully understood. Inflammation is …
neuroscience world, yet the complex pathogenicity is not fully understood. Inflammation is …
Alzheimer's disease failed clinical trials
S Asher, R Priefer - Life sciences, 2022 - Elsevier
Alzheimer's disease is a progressive neurodegenerative disease typically presenting with
symptoms of memory loss and cognitive decline. Existing theories for the causation of this …
symptoms of memory loss and cognitive decline. Existing theories for the causation of this …
BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease
Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain disorder
with no current cure. One of the important therapeutic approaches of AD is the inhibition of β …
with no current cure. One of the important therapeutic approaches of AD is the inhibition of β …
Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …
aging population worldwide. The enormous challenge which AD possesses to global …
[HTML][HTML] Alzheimer's disease drug development pipeline: 2017
J Cummings, G Lee, T Mortsdorf, A Ritter… - Alzheimer's & Dementia …, 2017 - Elsevier
Introduction There is an urgent need to develop new treatments for Alzheimer's disease (AD)
and to understand the drug development process for new AD therapies. Methods We …
and to understand the drug development process for new AD therapies. Methods We …
Targeting tumor necrosis factor alpha for Alzheimer's disease
B Decourt, DK Lahiri… - Current Alzheimer …, 2017 - ingentaconnect.com
Alzheimer's disease (AD) affects an estimated 44 million individuals worldwide, yet no
therapeutic intervention is available to stop the progression of the dementia …
therapeutic intervention is available to stop the progression of the dementia …
Molecular basis of familial and sporadic Alzheimer's disease
J Dorszewska, M Prendecki… - Current Alzheimer …, 2016 - ingentaconnect.com
Alzheimer's disease (AD) is a multifactorial disease with genetic (70%) and environmental
(30%) causes. Among the genetic factors are genes associated with a family history of the …
(30%) causes. Among the genetic factors are genes associated with a family history of the …
Therapies for prevention and treatment of Alzheimer's disease
J Mendiola-Precoma, LC Berumen… - BioMed research …, 2016 - Wiley Online Library
Alzheimer's disease (AD) is the most common cause of dementia associated with a
progressive neurodegenerative disorder, with a prevalence of 44 million people throughout …
progressive neurodegenerative disorder, with a prevalence of 44 million people throughout …
Current research therapeutic strategies for Alzheimer's disease treatment
Alzheimer's disease (AD) currently presents one of the biggest healthcare issues in the
developed countries. There is no effective treatment capable of slowing down disease …
developed countries. There is no effective treatment capable of slowing down disease …
Mesenchymal stem cell-derived exosomes ameliorate Alzheimer's disease pathology and improve cognitive deficits
YA Chen, CH Lu, CC Ke, SJ Chiu, FS Jeng, CW Chang… - Biomedicines, 2021 - mdpi.com
The accumulation of extracellular β-amyloid (Aβ) plaques within the brain is unique to
Alzheimer's disease (AD) and thought to induce synaptic deficits and neuronal loss. Optimal …
Alzheimer's disease (AD) and thought to induce synaptic deficits and neuronal loss. Optimal …