Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer's disease

D Kaur, V Sharma, R Deshmukh - Inflammopharmacology, 2019 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease that is of high importance to the
neuroscience world, yet the complex pathogenicity is not fully understood. Inflammation is …

Alzheimer's disease failed clinical trials

S Asher, R Priefer - Life sciences, 2022 - Elsevier
Alzheimer's disease is a progressive neurodegenerative disease typically presenting with
symptoms of memory loss and cognitive decline. Existing theories for the causation of this …

BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease

NM Moussa‐Pacha, SM Abdin, HA Omar… - Medicinal research …, 2020 - Wiley Online Library
Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain disorder
with no current cure. One of the important therapeutic approaches of AD is the inhibition of β …

Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies

P Sharma, P Srivastava, A Seth, PN Tripathi… - Progress in …, 2019 - Elsevier
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …

[HTML][HTML] Alzheimer's disease drug development pipeline: 2017

J Cummings, G Lee, T Mortsdorf, A Ritter… - Alzheimer's & Dementia …, 2017 - Elsevier
Introduction There is an urgent need to develop new treatments for Alzheimer's disease (AD)
and to understand the drug development process for new AD therapies. Methods We …

Targeting tumor necrosis factor alpha for Alzheimer's disease

B Decourt, DK Lahiri… - Current Alzheimer …, 2017 - ingentaconnect.com
Alzheimer's disease (AD) affects an estimated 44 million individuals worldwide, yet no
therapeutic intervention is available to stop the progression of the dementia …

Molecular basis of familial and sporadic Alzheimer's disease

J Dorszewska, M Prendecki… - Current Alzheimer …, 2016 - ingentaconnect.com
Alzheimer's disease (AD) is a multifactorial disease with genetic (70%) and environmental
(30%) causes. Among the genetic factors are genes associated with a family history of the …

Therapies for prevention and treatment of Alzheimer's disease

J Mendiola-Precoma, LC Berumen… - BioMed research …, 2016 - Wiley Online Library
Alzheimer's disease (AD) is the most common cause of dementia associated with a
progressive neurodegenerative disorder, with a prevalence of 44 million people throughout …

Current research therapeutic strategies for Alzheimer's disease treatment

J Folch, D Petrov, M Ettcheto, S Abad… - Neural …, 2016 - Wiley Online Library
Alzheimer's disease (AD) currently presents one of the biggest healthcare issues in the
developed countries. There is no effective treatment capable of slowing down disease …

Mesenchymal stem cell-derived exosomes ameliorate Alzheimer's disease pathology and improve cognitive deficits

YA Chen, CH Lu, CC Ke, SJ Chiu, FS Jeng, CW Chang… - Biomedicines, 2021 - mdpi.com
The accumulation of extracellular β-amyloid (Aβ) plaques within the brain is unique to
Alzheimer's disease (AD) and thought to induce synaptic deficits and neuronal loss. Optimal …