The Hippo signaling pathway regulates developmental organ growth, regeneration, and cell
fate decisions. Although the role of the Hippo pathway, and its transcriptional effectors YAP …

Abstract Hippo Tumor Suppressor Pathway is the main pathway for cell growth that
regulates tissue enlargement and organ size by limiting cell growth. This pathway is …

Hippo-YAP signaling pathway functions in early lineage differentiation of pluripotent stem
cells, but the detailed mechanisms remain elusive. We found that knockout (KO) of Mst1 and …

The first two differentiation events in the embryo result in three cell types–epiblast,
trophectoderm (TE) and hypoblast. The purpose here was to identify molecular markers for …

Regulatory T cells (Tregs) play crucial roles in maintaining immune tolerance. The
transcription factor Foxp3 is a critical regulator of Treg development and function, and its …

Purpose High frequency of aneuploidy in meiosis and cleavage stage coincides with waves
of epigenetic genome reprogramming that may indicate a possible association between …

The time required for successful blastocyst formation varies among multiple species. The
formation of a blastocyst is governed by numerous molecular cell signaling pathways, such …

Abstract Achaete scute-like 2 (Ascl2) is the Wnt signaling target, its regulation by other
signaling is undefined. Now we demonstrated that CD133+/CD44+ cell population from HT …

Ascl2 has been shown to be involved in tumorigenesis in colorectal cancer (CRC), although
its epigenetic regulatory mechanism is largely unknown. Here, we found that methylation of …

Blastocyst formation is an important milestone during preimplantation embryo development.
During murine preimplantation embryogenesis, the Hippo signalling pathway is known to …