Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …

Centrosomes are non-membrane-bound compartments that nucleate microtubule arrays.
They consist of nanometer-scale centrioles surrounded by a micron-scale, dynamic …

The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

Liquid–liquid phase separation is a key organizational principle in eukaryotic cells, on par
with intracellular membranes. It allows cells to concentrate specific proteins into …

Cells compartmentalize biochemical reactions using organelles. Organelles can be either
membrane-bound compartments or supramolecular assemblies of protein and ribonucleic …

A centrosome consists of two barrel-shaped centrioles embedded in a matrix of proteins
known as the pericentriolar material (PCM). The PCM serves as a platform for protein …

Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

Formation of one procentriole next to each pre-existing centriole is essential for centrosome
duplication, robust bipolar spindle assembly and maintenance of genome integrity …

The centrosome was discovered in the late 19th century when mitosis was first described.
Long recognized as a key organelle of the spindle pole, its core component, the centriole …