[HTML][HTML] The role of PD-1 in acute and chronic infection
JM Jubel, ZR Barbati, C Burger, DC Wirtz… - Frontiers in …, 2020 - frontiersin.org
PD-1 as an immune checkpoint molecule down-regulates T cell activity during immune
responses in order to prevent autoimmune tissue damage. In chronic infections or tumors …
responses in order to prevent autoimmune tissue damage. In chronic infections or tumors …
[HTML][HTML] Post-exposure treatments for Ebola and Marburg virus infections
RW Cross, CE Mire, H Feldmann… - Nature Reviews Drug …, 2018 - nature.com
The filoviruses—Ebola virus and Marburg virus—cause lethal haemorrhagic fever in
humans and non-human primates (NHPs). Filoviruses present a global health threat both as …
humans and non-human primates (NHPs). Filoviruses present a global health threat both as …
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
INTRODUCTION Many patients with coronavirus disease 2019 (COVID-19), caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with …
Comprehensive mapping of immune perturbations associated with severe COVID-19
L Kuri-Cervantes, MB Pampena, W Meng… - Science …, 2020 - science.org
Although critical illness has been associated with SARS-CoV-2–induced hyperinflammation,
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …
Thymosin alpha 1 reduces the mortality of severe coronavirus disease 2019 by restoration of lymphocytopenia and reversion of exhausted T cells
Y Liu, Y Pan, Z Hu, M Wu, C Wang… - Clinical Infectious …, 2020 - academic.oup.com
Background Thymosin alpha 1 (Tα1) had been used in the treatment of viral infections as an
immune response modifier for many years. However, clinical benefits and the mechanism of …
immune response modifier for many years. However, clinical benefits and the mechanism of …
[HTML][HTML] Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions
COVID-19 has become a global pandemic. Immune dysregulation has been implicated, but
immune responses remain poorly understood. We analyzed 71 COVID-19 patients …
immune responses remain poorly understood. We analyzed 71 COVID-19 patients …
[HTML][HTML] Persistent High Percentage of HLA-DR+CD38high CD8+ T Cells Associated With Immune Disorder and Disease Severity of COVID-19
J Du, L Wei, G Li, M Hua, Y Sun, D Wang… - Frontiers in …, 2021 - frontiersin.org
Background The global outbreak of coronavirus disease 2019 (COVID-19) has turned into a
worldwide public health crisis and caused more than 100,000,000 severe cases …
worldwide public health crisis and caused more than 100,000,000 severe cases …
[HTML][HTML] The development of broad-spectrum antiviral medical countermeasures to treat viral hemorrhagic fevers caused by natural or weaponized virus infections
MR Hickman, DL Saunders, CA Bigger… - PLoS neglected …, 2022 - journals.plos.org
The Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear
Defense (JPEO-CBRND) began development of a broad-spectrum antiviral countermeasure …
Defense (JPEO-CBRND) began development of a broad-spectrum antiviral countermeasure …
[PDF][PDF] Thymosin alpha 1 (Tα1) reduces the mortality of severe COVID-19 by restoration of lymphocytopenia and reversion of exhausted T cells
Y Liu, Y Pang, Z Hu, M Wu, C Wang, Z Feng… - Clin Infect …, 2020 - researchgate.net
Background. We previously reported that lymphocytopenia and T cell exhaustion is notable
in acute COVID19 patients, especially in aged and severe cases. Thymosin alpha 1 (Tα1) …
in acute COVID19 patients, especially in aged and severe cases. Thymosin alpha 1 (Tα1) …
The immune response as a double‐edged sword: The lesson learnt during the COVID‐19 pandemic
The COVID‐19 pandemic has represented an unprecedented challenge for the humanity,
and scientists around the world provided a huge effort to elucidate critical aspects in the fight …
and scientists around the world provided a huge effort to elucidate critical aspects in the fight …