Discovered two decades ago, Piwi-interacting RNAs (piRNAs) play critical roles in gene
regulation, transposon element repression, and antiviral defense. Dysregulation of piRNAs …

Reversible phase separation underpins the role of FUS in ribonucleoprotein granules and
other membrane-free organelles and is, in part, driven by the intrinsically disordered low …

The classic roles of mitochondria in energy production, metabolism, and apoptosis have
been well defined. However, a growing body of evidence suggests that mitochondria are …

Despite continuous expansion of the RNA binding protein (RBP) world, there is a lack of
systematic understanding of RBPs in the mammalian testis, which harbors one of the most …

The intermitochondrial cement (IMC) and chromatoid body (CB) are posited as central sites
for piRNA activity in mice, with MIWI initially assembling in the IMC for piRNA processing …

piRNAs play a critical role in the regulation of transposons and other germline genes. In
Caenorhabditis elegans, regulation of piRNA target genes is mediated by the mutator …

PIWI proteins and their associated piRNAs act to silence transposons and promote
gametogenesis. Murine PIWI proteins MIWI, MILI, and MIWI2 have multiple arginine and …

Many RNA binding proteins, including FUS, contain moderately repetitive, low complexity,
intrinsically disordered domains. These sequence motifs have recently been found to …

Arginine methylation is a ubiquitous and relatively stable post-translational modification
(PTM) that occurs in three types: monomethylarginine (MMA), asymmetric dimethylarginine …

PIWI-interacting RNAs (piRNAs) engage PIWI proteins to silence transposons and promote
germ cell development in animals. In diverse species, piRNA biogenesis occurs near the …