De-escalation strategies of (chemo) radiation for head-and-neck squamous cell cancers—HPV and beyond

A Rühle, AL Grosu, NH Nicolay - Cancers, 2021 - mdpi.com
Simple Summary HPV-related oropharyngeal squamous cell carcinoma patients have a very
good prognosis but are often suffering from long-term treatment-induced toxicities …

Expert consensus statement: Management of dysphagia in head and neck cancer patients

MA Kuhn, MB Gillespie, SL Ishman… - … –Head and Neck …, 2023 - Wiley Online Library
Objective To develop an expert consensus statement (ECS) on the management of
dysphagia in head and neck cancer (HNC) patients to address controversies and offer …

Efficacy and quality-of-life following involved nodal radiotherapy for head and neck squamous cell carcinoma: the INRT-AIR phase II clinical trial

DJ Sher, DH Moon, D Vo, J Wang, L Chen… - Clinical Cancer …, 2023 - AACR
Purpose: Elective neck irradiation (ENI) has long been considered mandatory when treating
head and neck squamous cell carcinoma (HNSCC) with definitive radiotherapy, but it is …

TORPEdO: A phase III trial of intensity-modulated proton beam therapy versus intensity-modulated radiotherapy for multi-toxicity reduction in oropharyngeal cancer

DJ Thomson, C Cruickshank, H Baines… - Clinical and …, 2023 - ctro.science
2. Design TORPEdO is a phase III multi-centre open-label randomised controlled trial to
assess whether intensity modulated proton therapy (IMPT) compared IMRT reduces …

Early-stage glottic squamous cell carcinoma in the era of image-guided radiotherapy

A Gupta, KH Wong, K Newbold, S Bhide… - Frontiers in …, 2021 - frontiersin.org
Early-stage squamous cell cancer (SCC) of the glottis has a good prognosis. Therefore,
patients have long survival outcomes and may potentially suffer from late toxicities of …

Patient-reported outcomes-guided adaptive radiation therapy for head and neck cancer

S Weppler, H Quon, C Schinkel, A Yarschenko… - Frontiers in …, 2021 - frontiersin.org
Purpose To identify which patient-reported outcomes (PROs) may be most improved through
adaptive radiation therapy (ART) with the goal of reducing toxicity incidence among head …

Pharyngeal constrictor dose–volume histogram metrics and patient-reported dysphagia in head and neck radiotherapy

O Paetkau, S Weppler, J Kwok, HC Quon… - Clinical Oncology, 2024 - Elsevier
Aims Head and neck radiotherapy long-term survival continues to improve and the
management of long-term side-effects is moving to the forefront of patient care. Dysphagia is …

Long-term update of NRG/RTOG 0522: A randomized phase 3 trial of concurrent radiation and cisplatin with or without cetuximab in locoregionally advanced head …

JJ Caudell, PA Torres-Saavedra, DI Rosenthal… - International Journal of …, 2023 - Elsevier
Purpose The combination of cisplatin and radiation or cetuximab and radiation improves
overall survival of patients with locoregionally advanced head and neck carcinoma. NRG …

In silico evaluation and feasibility of near margin-less head and neck daily adaptive radiotherapy

M Dohopolski, J Visak, B Choi, B Meng… - Radiotherapy and …, 2024 - Elsevier
Objective We explore the potential dosimetric benefits of reducing treatment volumes
through daily adaptive radiation therapy for head and neck cancer (HNC) patients using the …

[HTML][HTML] Survival and Swallowing Function after Primary Radiotherapy versus Transoral Robotic Surgery for Human Papillomavirus-Associated Oropharyngeal …

RT Hughes, BJ Levine, N May, RF Shenker, JH Yang… - ORL, 2023 - karger.com
Introduction: The aim of this study was to investigate the impact of primary transoral robotic
surgery (TORS) versus radiotherapy (RT) on progression-free survival (PFS), overall survival …