Fundus autofluorescence (FAF) imaging is an in vivo imaging method that allows for
topographic mapping of naturally or pathologically occurring intrinsic fluorophores of the …

Fundus-controlled perimetry (FCP, also called 'microperimetry') allows for spatially-resolved
mapping of visual sensitivity and measurement of fixation stability, both in clinical practice as …

Importance Sensitive outcome measures for disease progression are needed for treatment
trials in geographic atrophy (GA) secondary to age-related macular degeneration (AMD) …

Endpoint development trials are underway across the spectrum of retinal disease. New
validated endpoints are urgently required for the assessment of emerging gene therapies …

Preservation of photoreceptors beyond areas of retinal pigment epithelium atrophy is a
critical treatment goal in eyes with geographic atrophy (GA) to prevent vision loss. Thus, we …

Dark adaptation (DA) refers to the slow recovery of visual sensitivity in darkness following
exposure to intense or prolonged illumination, which bleaches a significant amount of the …

Purpose To investigate the association between retinal microstructure and cone and rod
function in geographic atrophy (GA) secondary to age-related macular degeneration (AMD) …

Spatially-resolved mapping of rod-and cone-function may facilitate monitoring of macular
diseases and serve as a functional outcome parameter. However, mesopic and dark …

Purpose To correlate choriocapillaris (CC) flow deficits (FD) in eyes with geographic atrophy
(GA) at various distances from the border of the GA lesion with yearly enlargement rate …

Sensitive and robust outcome measures of retinal function are pivotal for clinical trials in age-
related macular degeneration (AMD). A recent development is the implementation of …