Network medicine and artificial intelligence in cancer precision therapy: path to prevent drug-induced toxic side effect

AB Das - Current Opinion in Toxicology, 2024 - Elsevier
The discovery of cancer-specific therapeutics and determining their sensitivity is a critical
step in preventing drug-induced toxicity. Drug sensitivity varies among cancer patients due …

[HTML][HTML] Targeting PCSK9 reduces cancer cell stemness and enhances antitumor immunity in head and neck cancer

QC Yang, S Wang, YT Liu, A Song, ZZ Wu, SC Wan… - Iscience, 2023 - cell.com
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has been demonstrated to play a
critical role in regulating cholesterol homeostasis and T cell antitumor immunity. However …

[HTML][HTML] CGPA: multi-context insights from the cancer gene prognosis atlas

B Cao, X Yu, G Gonzalez, AR Murthy, T Li, Y Shen… - …, 2024 - pmc.ncbi.nlm.nih.gov
Cancer transcriptomic data are used extensively to interrogate the prognostic value of
targeted genes, yet basic scientists and clinicians have predominantly relied on univariable …