Resistant hypertension: detection, evaluation, and management: a scientific statement from the American Heart Association

RM Carey, DA Calhoun, GL Bakris, RD Brook… - …, 2018 - Am Heart Assoc
Resistant hypertension (RH) is defined as above-goal elevated blood pressure (BP) in a
patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a …

What is resistant arterial hypertension?

EV Shalaeva, FH Messerli - Blood pressure, 2023 - Taylor & Francis
Purpose The current review is to describe the definition and prevalence of resistant arterial
hypertension (RAH), the difference between refractory hypertension, patient characteristics …

[HTML][HTML] Clinical and pharmacogenetic impact of endothelial nitric oxide synthase polymorphisms on cardiovascular diseases

GH Oliveira-Paula, R Lacchini, JE Tanus-Santos - Nitric Oxide, 2017 - Elsevier
Nitric oxide (NO) is a vasoactive substance synthesized from l-arginine by neuronal (NOS1),
endothelial (NOS3), and inducible (NOS2) nitric oxide synthases. NOS3 is the most …

The Role of Single-Nucleotide Variants of NOS1, NOS2, and NOS3 Genes in the Comorbidity of Arterial Hypertension and Tension-Type Headache

NA Shnayder, MM Petrova, PV Moskaleva… - Molecules, 2021 - mdpi.com
Patients with tension-type headache (TTH) have an increased risk of developing arterial
hypertension (AH), while hypertensive subjects do seem to have an increased risk of TTH …

The global burden of resistant hypertension and potential treatment options

G Buso, C Agabiti-Rosei, M Lemoli… - European …, 2024 - pmc.ncbi.nlm.nih.gov
Resistant hypertension (RH) is defined as systolic blood pressure (SBP) or diastolic blood
pressure (DBP) that remains. 140 mmHg or. 90 mmHg, respectively, despite an appropriate …

Bifidobacterium longum CCFM752 prevented hypertension and aortic lesion, improved antioxidative ability, and regulated the gut microbiome in spontaneously …

W Lu, Y Wang, Z Fang, H Wang, J Zhu, Q Zhai… - Food & Function, 2022 - pubs.rsc.org
Oxidative stress and gut dysbiosis are important risk factors for hypertension. In this study,
the preventive effect of Bifidobacterium longum CCFM752 (CCFM752) on hypertension was …

[HTML][HTML] Mechanisms impairing blood pressure responses to nitrite and nitrate

GH Oliveira-Paula, LC Pinheiro, JE Tanus-Santos - Nitric Oxide, 2019 - Elsevier
Hypertension is a multifactorial disease associated with impaired nitric oxide (NO)
production and bioavailability. In this respect, restoring NO activity by using nitrite and nitrate …

Inducible nitric oxide synthase as a possible target in hypertension

GH Oliveira-Paula, R Lacchini… - Current drug …, 2014 - ingentaconnect.com
Nitric oxide (NO) is an important vasodilator produced by vascular endothelium. Its
enzymatic formation is derived from three different synthases: neuronal (nNOS), endothelial …

[HTML][HTML] Excessive dietary sodium intake and elevated blood pressure: a review of current prevention and management strategies and the emerging role of …

OM Dong - BMJ nutrition, prevention & health, 2018 - ncbi.nlm.nih.gov
INTRODUCTION Precision medicine has the potential to improve current standard of care
for patients, especially in the cardiovascular field. Better prevention and treatment of …

Gene–Gene Interactions Among PRKCA, NOS3 and BDKRB2 Polymorphisms Affect the Antihypertensive Effects of Enalapril

GH Oliveira‐Paula, MR Luizon… - Basic & Clinical …, 2017 - Wiley Online Library
Protein kinase C (PKC) signalling is critically involved in the control of blood pressure.
Angiotensin‐converting enzyme inhibitors (ACEi) affect PKC expression and activity, which …