In Vitro and Ex Vivo Models for Assessing Drug Permeation across the Cornea
I De Hoon, R Boukherroub, SC De Smedt… - Molecular …, 2023 - ACS Publications
Drug permeation across the cornea remains a major challenge due to its unique and
complex anatomy and physiology. Static barriers such as the different layers of the cornea …
complex anatomy and physiology. Static barriers such as the different layers of the cornea …
[HTML][HTML] Rethinking of TEER measurement reporting for epithelial cells grown on permeable inserts
BB Karakocak, S Keshavan, G Gunasingam… - European Journal of …, 2023 - Elsevier
Transepithelial electrical resistance (TEER) measures electrical resistance across epithelial
tissue barriers involving confluent layer (s) of cells. TEER values act as a prerequisite for …
tissue barriers involving confluent layer (s) of cells. TEER values act as a prerequisite for …
[HTML][HTML] Tailoring surface properties of liposomes for dexamethasone intraocular administration
Diseases of the posterior eye segment are often characterized by intraocular inflammation,
which causes, in the long term, severe impairment of eye functions and, ultimately, vision …
which causes, in the long term, severe impairment of eye functions and, ultimately, vision …
Augmented ocular uptake and anti-inflammatory efficacy of decorated Genistein-loaded NLCs incorporated in in situ gel
Genistein (Gen); a naturally occurring isoflavone, acts as a tyrosine kinase inhibitor and
efficiently downregulates inflammatory cytokines, which are pivotal in eye inflammation …
efficiently downregulates inflammatory cytokines, which are pivotal in eye inflammation …
Development and in-vitro evaluation of dexamethasone enriched nanoemulsion for ophthalmic indication
Background: Dexamethasone (DEX) is a glucocorticosteroid used in the treatment of steroid-
responsive inflammatory conditions of the eye. The currently marketed formulations pose …
responsive inflammatory conditions of the eye. The currently marketed formulations pose …
Nano-emulsomes for back of the eye delivery of Ganciclovir: formulation optimization, characterization & in vitro/in vivo evaluation
In this work, novel carriers-nanoemulsomes (NE) of ganciclovir (GCV) and a fluorescent
marker sodium fluorescein (SF) were developed and evaluated for posterior ocular delivery …
marker sodium fluorescein (SF) were developed and evaluated for posterior ocular delivery …
Dendronized polymeric biomaterial for loading, stabilization, and targeted cytosolic delivery of microRNA in cancer cells
MicroRNAs (miRNAs) are small non-coding RNAs involved in the fine-tuning of gene
regulation. Anti-miRNA is a promising RNA-interference (RNAi) agent that potently regulates …
regulation. Anti-miRNA is a promising RNA-interference (RNAi) agent that potently regulates …