Tumor buster-where will the CAR-T cell therapy 'missile'go?
Chimeric antigen receptor (CAR) T cell (CAR-T cell) therapy based on gene editing
technology represents a significant breakthrough in personalized immunotherapy for human …
technology represents a significant breakthrough in personalized immunotherapy for human …
Immunotherapy of neuroendocrine neoplasms: any role for the chimeric antigen receptor T cells?
Simple Summary Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of
tumors arising in different organs whose clinical course is variable according to histological …
tumors arising in different organs whose clinical course is variable according to histological …
A novel exosome based therapeutic intervention against neuroendocrine prostate cancer
Neuroendocrine prostate cancer (NEPC) is a highly lethal variant of castration-resistant
prostate cancer (CRPC) with poor survival rates. Current treatment options for NEPC are …
prostate cancer (CRPC) with poor survival rates. Current treatment options for NEPC are …
Chimeric antigen receptor-T cells are effective against CEACAM5 expressing non-small cell lung cancer cells resistant to antibody-drug conjugates
Chimeric antigen receptor-T (CAR-T) cells and antibody-drug conjugates (ADCs) are
promising therapeutic strategies in oncology. The carcinoembryonic antigen-related cell …
promising therapeutic strategies in oncology. The carcinoembryonic antigen-related cell …
[HTML][HTML] Human antibodies targeting ENPP1 as candidate therapeutics for cancers
Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is a type II transmembrane
glycoprotein expressed in many tissues. High expression levels of ENPP1 have been …
glycoprotein expressed in many tissues. High expression levels of ENPP1 have been …
Fully human monoclonal antibody targeting activated ADAM10 on colorectal cancer cells
N Saha, DS Baek, RP Mendoza, D Robev, Y Xu… - Biomedicine & …, 2023 - Elsevier
Metastasis and chemoresistance in colorectal cancer are mediated by certain poorly
differentiated cancer cells, known as cancer stem cells, that are maintained by Notch …
differentiated cancer cells, known as cancer stem cells, that are maintained by Notch …
Sequencing and Bioinformatics analysis of lncRNA/circRNA-miRNA-mRNA in Glioblastoma multiforme
R Wang, Q Li, X Chu, N Li, H Liang, F He - Metabolic Brain Disease, 2023 - Springer
Evidence suggests that non-coding RNAs have a role in glioblastoma multiforme (GBM),
although the regulatory mechanisms controlled by competing endogenous RNAs (ceRNAs) …
although the regulatory mechanisms controlled by competing endogenous RNAs (ceRNAs) …
A novel human single-domain antibody-drug conjugate targeting CEACAM5 exhibits potent in vitro and in vivo antitumor activity
X Zhu, Q Li, Y Kong, K Huang, G Wang… - Acta Pharmacologica …, 2024 - nature.com
Leveraging the specificity of antibody to deliver cytotoxic agent into tumor, antibody-drug
conjugates (ADCs) have become one of the hotspots in the development of anticancer …
conjugates (ADCs) have become one of the hotspots in the development of anticancer …
New CEACAM-targeting 2A3 single-domain antibody-based chimeric antigen receptor T-cells produce anticancer effects in vitro and in vivo
I Jancewicz, M Śmiech, M Winiarska… - Cancer Immunology …, 2024 - Springer
Recently, a breakthrough immunotherapeutic strategy of chimeric antigen receptor (CAR) T-
cells has been introduced to hematooncology. However, to apply this novel treatment in …
cells has been introduced to hematooncology. However, to apply this novel treatment in …
Discovery of a novel highly specific, fully human PSCA antibody and its application as an antibody-drug conjugate in prostate cancer
Prostate stem cell antigen (PSCA) is expressed in all stages of prostate cancer, including in
advanced androgen-independent tumors and bone metastasis. PSCA may associate with …
advanced androgen-independent tumors and bone metastasis. PSCA may associate with …