Neurological disorders are becoming a growing burden as society ages, and there is a
compelling need to address this spiraling problem. Stem cell‐based regenerative medicine …

While glia are essential for regulating the homeostasis in the normal brain, their dysfunction
contributes to neurodegeneration in many brain diseases, including Parkinson's disease …

Astrocytes are critical components of the neurovascular unit that support blood-brain barrier
(BBB) function. Pathological transformation of astrocytes to reactive states can be protective …

Increasing attention has been paid to the diseases of central nervous system (CNS). The
penetration efficiency of most CNS drugs into the brain parenchyma is rather limited due to …

Activation of microglia by classical inflammatory mediators can convert astrocytes into a
neurotoxic A1 phenotype in a variety of neurological diseases,. Development of agents that …

An estimated 20% of all patients with cancer will develop brain metastases, with the majority
of brain metastases occurring in those with lung, breast and colorectal cancers, melanoma …

Therapies directed toward the central nervous system remain difficult to translate into
improved clinical outcomes. This is largely due to the blood–brain barrier (BBB), arguably …

Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson
disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis …

Cell-replacement therapies have long been an attractive prospect for treating Parkinson
disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with …

The blood–brain barrier (BBB) is a vital boundary between neural tissue and circulating
blood. The BBB's unique and protective features control brain homeostasis as well as ion …