SARS-CoV-2 infection poses a major threat to the lungs and multiple other organs,
occasionally causing death. Until effective vaccines are developed to curb the pandemic, it …

Infection with SARS-CoV-2, the causative agent of the Coronavirus disease 2019 (COVID-
19) pandemic, causes respiratory problems and multifaceted organ dysfunction. A crucial …

Unusually for a viral infection, the immunological phenotype of severe COVID-19 is
characterised by a depleted lymphocyte and elevated neutrophil count, with the neutrophil …

Stroke is a threatening cerebrovascular disease caused by thrombus with high morbidity
and mortality rates. Neutrophils are the first to be recruited in the brain after stroke, which …

ABSTRACT Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus type 2 (SARS-CoV-2), has been associated mainly with a range of …

Neutrophils release neutrophil extracellular traps (NETs) to trap pathogenic microorganisms.
NETs are involved in the inflammatory response and bacterial killing and clearance …

The SARS-CoV-2 virus gains entry to cells by binding to angiotensin-converting enzyme 2
(ACE2). Since circumventricular organs and parts of the hypothalamus lack a blood–brain …

Despite ongoing vaccination COVID-19 is a global healthcare problem because of the lack
of an effective targeted therapy. In severe COVID-19 manifesting as acute respiratory …

Rapid recruitment of neutrophils to an inflamed site is one of the hallmarks of an effective
host defense mechanism. The main pathway through which this happens is by the innate …

During the COVID-19 pandemic, vaccination is the most important countermeasure.
Pharmacovigilance concerns however emerged with very rare, but potentially disastrous …