Organoruthenium-bipyridyl complexes–A platform for diverse chemistry and applications

C Pandya, A Sivaramakrishna - Coordination Chemistry Reviews, 2024 - Elsevier
The increasing impact of organometallic complexes of group 8–10 metals academically and
industrially over the years demonstrates remarkable progress in harvesting useful reagents …

Ruthenium (II)–Cyclopentadienyl-Derived Complexes as New Emerging Anti-Colorectal Cancer Drugs

C Teixeira-Guedes, AR Brás, RG Teixeira, A Valente… - Pharmaceutics, 2022 - mdpi.com
Colorectal cancer (CRC) is one of the most common malignancies and one of the leading
causes of cancer-related death worldwide, urging the need for new and more efficient …

Unprecedented inhibition of P-gp activity by a novel ruthenium-cyclopentadienyl compound bearing a bipyridine-biotin ligand

L Côrte-Real, B Karas, P Gírio, A Moreno… - European journal of …, 2019 - Elsevier
Two new ruthenium complexes,[Ru (η 5-Cp)(PPh 3)(2, 2'-bipy-4, 4'-R)]+ with R=-CH 2 OH
(Ru1) or dibiotin ester (Ru2) were synthesized and fully characterized. Both compounds …

Biotinylated Polymer-Ruthenium Conjugates: In Vitro and In Vivo Studies in a Triple-Negative Breast Cancer Model

L Côrte-Real, AR Brás, A Pilon, N Mendes, AS Ribeiro… - Pharmaceutics, 2022 - mdpi.com
The need for new therapeutic approaches for triple-negative breast cancer is a clinically
relevant problem that needs to be solved. Using a multi-targeting approach to enhance …

Ruthenium–Cyclopentadienyl Bipyridine–Biotin Based Compounds: Synthesis and Biological Effect

L Côrte-Real, B Karas, AR Brás, A Pilon… - Inorganic …, 2019 - ACS Publications
Prospective anticancer metallodrugs should consider target-specific components in their
design in order to overcome the limitations of the current chemotherapeutics. The inclusion …

Methyl-cyclopentadienyl ruthenium compounds with 2, 2′-bipyridine derivatives display strong anticancer activity and multidrug resistance potential

L Côrte-Real, RG Teixeira, P Gírio, E Comsa… - Inorganic …, 2018 - ACS Publications
New ruthenium methyl-cyclopentadienyl compounds bearing bipyridine derivatives with the
general formula [Ru (η5-MeCp)(PPh3)(4, 4′-R-2, 2′-bpy)]+(Ru1, R= H; Ru2, R= CH3; and …

A new family of iron (II)-cyclopentadienyl compounds shows strong activity against colorectal and triple negative breast cancer cells

A Pilon, AR Brás, L Côrte-Real, F Avecilla, PJ Costa… - Molecules, 2020 - mdpi.com
A family of compounds with the general formula [Fe (η5-C5H5)(CO)(PPh3)(NCR)]+ has
been synthesized (NCR= benzonitrile (1); 4-hydroxybenzonitrile (2); 4 …

Synthesis, characterization and antitumor properties of novel silver (I) and gold (I) N-heterocyclic carbene complexes

İ Özdemir, O Çiftçi, E Evren, N Gürbüz, N Kaloğlu… - Inorganica Chimica …, 2020 - Elsevier
In this study, two novel benzimidazolium salts consisting propane sulfonate order were
integrated in high yields as N-heterocyclic carbene (NHC) precursors. The silver-NHC …

Novel “ruthenium cyclopentadienyl”–peptide conjugate complexes against human FGFR (+) breast cancer

JF Machado, M Machuqueiro, F Marques… - Dalton …, 2020 - pubs.rsc.org
In this work we explored the possibility of improving the selectivity of a cytotoxic Ru complex
[RuCp (PPh3)(2, 2′-bipy)][CF3SO3](where Cp= η5-cyclopentadienyl) TM34 towards FGFR …

Polymeric micelle-mediated delivery of half-sandwich ruthenium (II) complexes with phosphanes derived from fluoroloquinolones for lung adenocarcinoma treatment

P Kołoczek, A Skórska-Stania, A Cierniak… - European Journal of …, 2018 - Elsevier
Novel half-sandwich ruthenium (II) complexes with aminomethyl (diphenyl) phosphine
derived from fluoroloquinolones (RuPCp, RuPSf, RuPLm, RuPNr) were being investigated …