The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …

As the incidence of hepatobiliary diseases increases, we must improve our understanding of
the molecular, cellular, and physiological factors that contribute to the pathogenesis of liver …

The endoderm germ layer contributes to the respiratory and gastrointestinal tracts and to all
of their associated organs. Over the past decade, studies in vertebrate model organisms …

Biliary Atresia is a devastating pediatric cholangiopathy affecting the bile ducts of the liver. In
this review, we describe recent progress in the understanding of liver development with a …

We developed an in vitro model system where induced pluripotent stem cells (iPSCs)
differentiate into 3-dimensional human hepatic organoids (HOs) through stages that …

Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …

Zebrafish provide a highly versatile model in which to study vertebrate development. Many
recent studies have elucidated early events in the organogenesis of the zebrafish pancreas; …

Liver development requires two linked processes: differentiation of the various hepatic cell
types from their embryonic progenitors and the arrangement of those cells into structures …

The ventral pancreas, biliary system, and liver arise from the posterior ventral foregut, but the
cell-intrinsic pathway by which these organ lineages are separated is not known. Here we …