PIWI-interacting RNAs: small RNAs with big functions
In animals, PIWI-interacting RNAs (piRNAs) of 21–35 nucleotides in length silence
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
B vitamins and one-carbon metabolism: implications in human health and disease
Vitamins B9 (folate) and B12 are essential water-soluble vitamins that play a crucial role in
the maintenance of one-carbon metabolism: a set of interconnected biochemical pathways …
the maintenance of one-carbon metabolism: a set of interconnected biochemical pathways …
Roles and regulation of histone methylation in animal development
Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …
arginine residues, and it can be governed by multiple positive and negative regulators, even …
Cellular pathways influenced by protein arginine methylation: Implications for cancer
Arginine methylation is an influential post-translational modification occurring on histones,
RNA binding proteins, and many other cellular proteins, affecting their function by altering …
RNA binding proteins, and many other cellular proteins, affecting their function by altering …
[HTML][HTML] Phase transition of a disordered nuage protein generates environmentally responsive membraneless organelles
Cells chemically isolate molecules in compartments to both facilitate and regulate their
interactions. In addition to membrane-encapsulated compartments, cells can form …
interactions. In addition to membrane-encapsulated compartments, cells can form …
RGG/RG motif regions in RNA binding and phase separation
PA Chong, RM Vernon, JD Forman-Kay - Journal of molecular biology, 2018 - Elsevier
Abstract RGG/RG motifs are RNA binding segments found in many proteins that can partition
into membraneless organelles. They occur in the context of low-complexity disordered …
into membraneless organelles. They occur in the context of low-complexity disordered …
Serine, glycine and one-carbon units: cancer metabolism in full circle
JW Locasale - Nature Reviews Cancer, 2013 - nature.com
One-carbon metabolism involving the folate and methionine cycles integrates nutritional
status from amino acids, glucose and vitamins, and generates diverse outputs, such as the …
status from amino acids, glucose and vitamins, and generates diverse outputs, such as the …
PIWI-interacting RNA: its biogenesis and functions
YW Iwasaki, MC Siomi, H Siomi - Annual review of biochemistry, 2015 - annualreviews.org
PIWI-interacting RNAs (piRNAs) are a class of small RNAs that are 24–31 nucleotides in
length. They associate with PIWI proteins, which constitute a germline-specific subclade of …
length. They associate with PIWI proteins, which constitute a germline-specific subclade of …
Protein arginine methyltransferases and cancer
Y Yang, MT Bedford - Nature Reviews Cancer, 2013 - nature.com
There are nine protein arginine methyltransferases (PRMTs) encoded in mammalian
genomes, the protein products of which catalyse three types of arginine methylation …
genomes, the protein products of which catalyse three types of arginine methylation …
Non-histone protein methylation as a regulator of cellular signalling and function
Abstract Methylation of Lys and Arg residues on non-histone proteins has emerged as a
prevalent post-translational modification and as an important regulator of cellular signal …
prevalent post-translational modification and as an important regulator of cellular signal …