As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic
invasions and endogenous cellular damage and responds by forming the NLRP3 …

Diseases associated with chronic inflammation constitute a major health burden across the
world. As central instigators of the inflammatory response to infection and tissue damage …

Inflammasomes are cytosolic innate immune complexes that activate caspase-1 following
detection of pathogenic and endogenous dangers,,,–, and NACHT-, leucine-rich repeat …

NLRP3 is an intracellular sensor protein that when activated by a broad spectrum of
exogenous and endogenous stimuli leads to inflammasome formation and pyroptosis,. The …

The nucleotide-binding, oligomerization domain-like receptor family pyrin domain containing
3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and …

Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

Inflammasomes are supramolecular complexes that form in the cytosol in response to
pathogen-associated and damage-associated stimuli, as well as other danger signals that …

Inflammasomes are supramolecular platforms that organize in response to various damage-
associated molecular patterns and pathogen-associated molecular patterns. Upon …

The nucleotide-binding domain (NBD), leucine-rich repeat (LRR), and pyrin domain (PYD)-
containing protein 3 (NLRP3) inflammasome is a critical mediator of the innate immune …

The innate immune system uses inflammasomal proteins to recognize danger signals and
fight invading pathogens. NLRP3, a multidomain protein belonging to the family of STAND …