Structural mechanisms of NLRP3 inflammasome assembly and activation
As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic
invasions and endogenous cellular damage and responds by forming the NLRP3 …
invasions and endogenous cellular damage and responds by forming the NLRP3 …
Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
L Vande Walle, M Lamkanfi - Nature Reviews Drug Discovery, 2024 - nature.com
Diseases associated with chronic inflammation constitute a major health burden across the
world. As central instigators of the inflammatory response to infection and tissue damage …
world. As central instigators of the inflammatory response to infection and tissue damage …
Cryo-EM structures of the active NLRP3 inflammasome disc
Inflammasomes are cytosolic innate immune complexes that activate caspase-1 following
detection of pathogenic and endogenous dangers,,,–, and NACHT-, leucine-rich repeat …
detection of pathogenic and endogenous dangers,,,–, and NACHT-, leucine-rich repeat …
Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3
IV Hochheiser, M Pilsl, G Hagelueken, J Moecking… - Nature, 2022 - nature.com
NLRP3 is an intracellular sensor protein that when activated by a broad spectrum of
exogenous and endogenous stimuli leads to inflammasome formation and pyroptosis,. The …
exogenous and endogenous stimuli leads to inflammasome formation and pyroptosis,. The …
Pharmacological inhibition of the NLRP3 inflammasome: structure, molecular activation, and inhibitor-NLRP3 interaction
Q Ma - Pharmacological reviews, 2023 - ASPET
The nucleotide-binding, oligomerization domain-like receptor family pyrin domain containing
3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and …
3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and …
The role of inflammasomes in human diseases and their potential as therapeutic targets
J Yao, K Sterling, Z Wang, Y Zhang… - Signal Transduction and …, 2024 - nature.com
Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …
signals and triggering the innate immune response. Each inflammasome complex has three …
Mechanistic insights from inflammasome structures
Inflammasomes are supramolecular complexes that form in the cytosol in response to
pathogen-associated and damage-associated stimuli, as well as other danger signals that …
pathogen-associated and damage-associated stimuli, as well as other danger signals that …
Uncoupled pyroptosis and IL-1β secretion downstream of inflammasome signaling
Y Li, Q Jiang - Frontiers in Immunology, 2023 - frontiersin.org
Inflammasomes are supramolecular platforms that organize in response to various damage-
associated molecular patterns and pathogen-associated molecular patterns. Upon …
associated molecular patterns and pathogen-associated molecular patterns. Upon …
ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation
S Zheng, X Que, S Wang, Q Zhou, X Xing, L Chen… - Molecular cell, 2023 - cell.com
The nucleotide-binding domain (NBD), leucine-rich repeat (LRR), and pyrin domain (PYD)-
containing protein 3 (NLRP3) inflammasome is a critical mediator of the innate immune …
containing protein 3 (NLRP3) inflammasome is a critical mediator of the innate immune …
ATP-binding and hydrolysis of human NLRP3
R Brinkschulte, DM Fußhöller, F Hoss… - Communications …, 2022 - nature.com
The innate immune system uses inflammasomal proteins to recognize danger signals and
fight invading pathogens. NLRP3, a multidomain protein belonging to the family of STAND …
fight invading pathogens. NLRP3, a multidomain protein belonging to the family of STAND …