Liver cancer has become the sixth most diagnosed cancer and the fourth leading cause of
cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75–85 …

Areas of hypoxic tumour tissue are known to be resistant to treatment and are associated
with a poor clinical prognosis. There are several reasons why this might be, including the …

Deubiquitylating enzymes (DUBs) play an essential role in targeted protein degradation and
represent an emerging therapeutic paradigm in cancer. However, their therapeutic potential …

Despite diversity in genetic events in oncogenesis, cancer cells exhibit a common set of
functional characteristics. Otto Warburg discovered that cancer cells have consistently …

A common set of functional characteristics of cancer cells is that cancer cells consume a
large amount of glucose, maintain high rate of glycolysis and convert a majority of glucose …

As a phenotypically plastic cellular population, macrophages change their physiology in
response to environmental signals. Emerging evidence suggests that macrophages are …

A high rate of glycolytic flux, even in the presence of oxygen, is a central metabolic hallmark
of neoplastic tumors. Cancer cells preferentially utilize glycolysis in order to satisfy their …

Enolase is a glycolytic enzyme, which catalyzes the inter-conversion of 2-phosphoglycerate
to phosphoenolpyruvate. Altered expression of this enzyme is frequently observed in cancer …

Cancer metastasis is the major cause of cancer-associated death. Accordingly, identification
of the regulatory mechanisms that control whether or not tumor cells become “directed …

MYC is deregulated in most tumour types, but an effective means to selectively target its
aberrant expression is not yet available. Supercoiling that is induced by transcription has …