The myosin phosphatase targeting protein (MYPT) family: a regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase …
ME Grassie, LD Moffat, MP Walsh… - Archives of biochemistry …, 2011 - Elsevier
The mammalian MYPT family consists of the products of five genes, denoted MYPT1,
MYPT2, MBS85, MYPT3 and TIMAP, which function as targeting and regulatory subunits to …
MYPT2, MBS85, MYPT3 and TIMAP, which function as targeting and regulatory subunits to …
Myosin phosphatase target subunit: Many roles in cell function
F Matsumura, DJ Hartshorne - Biochemical and biophysical research …, 2008 - Elsevier
Phosphorylation of myosin II is important in many aspects of cell function and involves a
myosin kinase, eg myosin light chain kinase, and a myosin phosphatase (MP). MP is …
myosin kinase, eg myosin light chain kinase, and a myosin phosphatase (MP). MP is …
[HTML][HTML] Phosphorylation of Thr695 and Thr850 on the myosin phosphatase target subunit: inhibitory effects and occurrence in A7r5 cells
Major sites for Rho-kinase on the myosin phosphatase target subunit (MYPT1) are Thr695
and Thr850. Phosphorylation of Thr695 inhibits phosphatase activity but the role of …
and Thr850. Phosphorylation of Thr695 inhibits phosphatase activity but the role of …
[HTML][HTML] Myosin phosphatase: Unexpected functions of a long-known enzyme
Myosin phosphatase (MP) holoenzyme is a Ser/Thr specific enzyme, which is the member of
protein phosphatase type 1 (PP1) family and composed of a PP1 catalytic subunit …
protein phosphatase type 1 (PP1) family and composed of a PP1 catalytic subunit …
Effects of oxygen on cell turnover and expression of regulators of apoptosis in human placental trophoblast
AEP Heazell, HA Lacey, CJP Jones, B Huppertz… - Placenta, 2008 - Elsevier
Pre-eclampsia (PE) and intrauterine growth restriction (IUGR) are associated with aberrant
cell turnover, including increased apoptosis, in placental villous trophoblast. The increased …
cell turnover, including increased apoptosis, in placental villous trophoblast. The increased …
[HTML][HTML] Dual role of poly (ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cells
Activation of poly (ADP-ribose) polymerase-1 (PARP1) has been shown to mediate cell
death induced by genotoxic stimuli. The role of poly (ADP-ribose) glycohydrolase (PARG) …
death induced by genotoxic stimuli. The role of poly (ADP-ribose) glycohydrolase (PARG) …
MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity
MJ Sandí, CB Marshall, M Balan, É Coyaud, M Zhou… - Science …, 2017 - science.org
The PAR-1–MARK pathway controls cell polarity through the phosphorylation of microtubule-
associated proteins. Rho-Rac guanine nucleotide exchange factor 2 (ARHGEF2), which …
associated proteins. Rho-Rac guanine nucleotide exchange factor 2 (ARHGEF2), which …
ROCK1 phosphorylates and activates zipper-interacting protein kinase
L Hagerty, DH Weitzel, J Chambers, CN Fortner… - Journal of Biological …, 2007 - ASBMB
Zipper-interacting protein kinase (ZIPK) regulates Ca 2+-independent phosphorylation of
both smooth muscle (to regulate contraction) and non-muscle myosin (to regulate non …
both smooth muscle (to regulate contraction) and non-muscle myosin (to regulate non …
PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells
Entry into mitosis is driven by the phosphorylation of thousands of substrates, under the
master control of Cdk1. During entry into mitosis, Cdk1, in collaboration with MASTL kinase …
master control of Cdk1. During entry into mitosis, Cdk1, in collaboration with MASTL kinase …
The short-chain fatty acid propionate inhibits adipogenic differentiation of human chorion-derived mesenchymal stem cells through the free fatty acid receptor 2
Free fatty acid receptor 2 (FFAR2, also known as GPR43) is a G-protein-coupled receptor
activated by short-chain fatty acids that are produced by gut microbiota through fermentation …
activated by short-chain fatty acids that are produced by gut microbiota through fermentation …