Histotripsy methods in mechanical disintegration of tissue: Towards clinical applications

VA Khokhlova, JB Fowlkes, WW Roberts… - International journal …, 2015 - Taylor & Francis
In high intensity focused ultrasound (HIFU) therapy, an ultrasound beam is focused within
the body to locally affect the targeted site without damaging intervening tissues. The most …

[HTML][HTML] For whom the bubble grows: physical principles of bubble nucleation and dynamics in histotripsy ultrasound therapy

KB Bader, E Vlaisavljevich, AD Maxwell - Ultrasound in medicine & biology, 2019 - Elsevier
Histotripsy is a focused ultrasound therapy for non-invasive tissue ablation. Unlike thermally
ablative forms of therapeutic ultrasound, histotripsy relies on the mechanical action of …

Histotripsy: a method for mechanical tissue ablation with ultrasound

Z Xu, TD Khokhlova, CS Cho… - Annual Review of …, 2024 - annualreviews.org
Histotripsy is a relatively new therapeutic ultrasound technology to mechanically liquefy
tissue into subcellular debris using high-amplitude focused ultrasound pulses. In contrast to …

The histotripsy spectrum: differences and similarities in techniques and instrumentation

RP Williams, JC Simon, VA Khokhlova… - International Journal …, 2023 - Taylor & Francis
Since its inception about two decades ago, histotripsy–a non-thermal mechanical tissue
ablation technique–has evolved into a spectrum of methods, each with distinct potentiating …

Computational modeling of thermal combination therapies by magneto-ultrasonic heating to enhance drug delivery to solid tumors

M Souri, M Soltani, F Moradi Kashkooli - Scientific reports, 2021 - nature.com
For the first time, inspired by magnetic resonance imaging-guidance high intensity focused
ultrasound (MR-HIFU) technology, ie, medication therapy and thermal ablation in one …

Low frequency nanobubble-enhanced ultrasound mechanotherapy for noninvasive cancer surgery

M Bismuth, S Katz, T Mano, R Aronovich, D Hershkovitz… - Nanoscale, 2022 - pubs.rsc.org
Scaling down the size of microbubble contrast agents to the nanometer level holds the
promise for noninvasive cancer therapy. However, the small size of nanobubbles limits the …

High-intensity focused ultrasound: current status for image-guided therapy

A Copelan, J Hartman, M Chehab… - Seminars in …, 2015 - thieme-connect.com
Image-guided high-intensity focused ultrasound (HIFU) is an innovative therapeutic
technology, permitting extracorporeal or endocavitary delivery of targeted thermal ablation …

Non-viral delivery of CRISPR/Cas cargo to the retina using nanoparticles: Current possibilities, challenges, and limitations

A Salman, A Kantor, ME McClements, G Marfany… - Pharmaceutics, 2022 - mdpi.com
The discovery of the CRISPR/Cas system and its development into a powerful genome
engineering tool have revolutionized the field of molecular biology and generated …

Boiling histotripsy ablation of renal cell carcinoma in the eker rat promotes a systemic inflammatory response

GR Schade, YN Wang, S D'Andrea, JH Hwang… - Ultrasound in medicine …, 2019 - Elsevier
Boiling histotripsy (BH) is an experimental focused ultrasound technique that produces non-
thermal mechanical ablation. We evaluated the feasibility, short-term histologic effects and …

A review on acoustic vortices: Generation, characterization, applications and perspectives

S Guo, Z Ya, P Wu, M Wan - Journal of Applied Physics, 2022 - pubs.aip.org
Acoustic vortices provide a single-beam approach to manipulate objects with sizes from
nanometers to millimeters, gaining increasing interest in recent years. The helical beam …