Multi-omics data integration considerations and study design for biological systems and disease
S Graw, K Chappell, CL Washam, A Gies, J Bird… - Molecular omics, 2021 - pubs.rsc.org
With the advancement of next-generation sequencing and mass spectrometry, there is a
growing need for the ability to merge biological features in order to study a system as a …
growing need for the ability to merge biological features in order to study a system as a …
Carbohydrates great and small, from dietary fiber to sialic acids: How glycans influence the gut microbiome and affect human health
Gut microbiome composition depends heavily upon diet and has strong ties to human
health. Dietary carbohydrates shape the gut microbiome by providing a potent nutrient …
health. Dietary carbohydrates shape the gut microbiome by providing a potent nutrient …
Genomic reconstruction of short-chain fatty acid production by the human gut microbiota
MS Frolova, IA Suvorova, SN Iablokov… - Frontiers in Molecular …, 2022 - frontiersin.org
Short-chain fatty acids (SCFAs) including acetate, formate, propionate, and butyrate are the
end products of dietary fiber and host glycan fermentation by the human gut microbiota …
end products of dietary fiber and host glycan fermentation by the human gut microbiota …
Understanding the mother-breastmilk-infant “triad”
L Bode, AS Raman, SH Murch, NC Rollins, JI Gordon - Science, 2020 - science.org
Breastfeeding and breastmilk exert remarkable influence on infant survival and health (1, 2),
including reduced risk from infections and promoting various aspects of postnatal …
including reduced risk from infections and promoting various aspects of postnatal …
Bacteroidota and Lachnospiraceae integration into the gut microbiome at key time points in early life are linked to infant neurodevelopment
K Oliphant, M Ali, M D'Souza, PD Hughes… - Gut …, 2021 - Taylor & Francis
The early life microbiome plays critical roles in host development, shaping long-term
outcomes including brain functioning. It is not known which initial infant colonizers elicit …
outcomes including brain functioning. It is not known which initial infant colonizers elicit …
Discovery and delivery strategies for engineered live biotherapeutic products
Genetically engineered microbes that secrete therapeutics, sense and respond to external
environments, and/or target specific sites in the gut fall under an emergent class of …
environments, and/or target specific sites in the gut fall under an emergent class of …
Experimental autoimmune encephalomyelitis is associated with changes of the microbiota composition in the gastrointestinal tract
The gut microbiome is known to be sensitive to changes in the immune system, especially
during autoimmune diseases such as Multiple Sclerosis (MS). Our study examines the …
during autoimmune diseases such as Multiple Sclerosis (MS). Our study examines the …
Perinatal development of innate immune topology
At the transition from intrauterine to postnatal life, drastic alterations are mirrored by changes
in cellular immunity. These changes are in part immune cell intrinsic, originate in the …
in cellular immunity. These changes are in part immune cell intrinsic, originate in the …
Microbes with higher metabolic independence are enriched in human gut microbiomes under stress
A wide variety of human diseases are associated with loss of microbial diversity in the
human gut, inspiring a great interest in the diagnostic or therapeutic potential of the …
human gut, inspiring a great interest in the diagnostic or therapeutic potential of the …
Gut microbiome development and childhood undernutrition
MJ Barratt, T Ahmed, JI Gordon - Cell host & microbe, 2022 - cell.com
Forty-five percent of deaths among children under 5 years of age are associated with
undernutrition. Globally, almost 200 million children exhibit the two major forms of …
undernutrition. Globally, almost 200 million children exhibit the two major forms of …