The 2‐Pyridyl Problem: Challenging Nucleophiles in Cross‐Coupling Arylations

XAF Cook, A de Gombert, J McKnight… - Angewandte …, 2021 - Wiley Online Library
Azine‐containing biaryls are ubiquitous scaffolds in many areas of chemistry, and efficient
methods for their synthesis are continually desired. Pyridine rings are prominent amongst …

Synthesis of piperidines

MGP Buffat - Tetrahedron, 2004 - Elsevier
Functionalised piperidines are among the most common building blocks in natural products,
and, more interestingly, in many biologically active compounds such as anopterine …

Boron science

NS Hosmane - New technologies and applications, 2011 - api.taylorfrancis.com
What is boron? The question itself may not seem very significant to many people. Their
introduction to the word “boron” could come as the butt of a joke. Conan O'Brien made jokes …

A general solution for unstable boronic acids: slow-release cross-coupling from air-stable MIDA boronates

DM Knapp, EP Gillis, MD Burke - Journal of the American …, 2009 - ACS Publications
Many boronic acids, including 2-heterocyclic, vinyl, and cyclopropyl derivatives, are
inherently unstable, which can limit their benchtop storage and/or efficient cross-coupling …

Light-induced Pd catalyst enables C(sp2)–C(sp2) cross-electrophile coupling bypassing the demand for transmetalation

S Maiti, P Ghosh, D Raja, S Ghosh, S Chatterjee… - Nature Catalysis, 2024 - nature.com
Transition metal-catalysed cross-coupling is a versatile tool for the construction of (hetero)
biaryl scaffolds. However, the cross-electrophile coupling using abundant (hetero) aryl …

Metalated heterocycles and their applications in synthetic organic chemistry

R Chinchilla, C Nájera, M Yus - Chemical reviews, 2004 - ACS Publications
The presence of heterocyclic moieties in all kinds of organic compounds of interest in
biology, pharmacology, optics, electronics, material sciences, and so on is sufficiently known …

[HTML][HTML] A general solution for the 2-pyridyl problem

GR Dick, EM Woerly, MD Burke - … Chemie (International ed. in …, 2012 - ncbi.nlm.nih.gov
Most small molecules are highly modular in their constitution, which suggests a potential
general capacity for simple, efficient, and flexible construction through iterative coupling of …

Recent developments in the chemistry of dihydropyridines

R Lavilla - Journal of the Chemical Society, Perkin Transactions 1, 2002 - pubs.rsc.org
Recent developments in the chemistry of dihydropyridines - Journal of the Chemical Society,
Perkin Transactions 1 (RSC Publishing) DOI:10.1039/B101371H Royal Society of Chemistry View …

[HTML][HTML] A general and efficient method for the Suzuki-Miyaura coupling of 2-pyridyl nucleophiles

KL Billingsley, SL Buchwald - Angewandte Chemie (International …, 2008 - ncbi.nlm.nih.gov
The Suzuki-Miyaura reaction has become one of the most valuable synthetic processes for
the construction of carbon-carbon bonds,[1] and our laboratories has developed many …

Stereospecific coupling of boronic esters with N-heteroaromatic compounds

J Llaveria, D Leonori, VK Aggarwal - Journal of the American …, 2015 - ACS Publications
A protocol for the stereospecific coupling of chiral secondary and tertiary boronic esters with
lithiated N-heteroaromatics is described. The process involves initial boronate complex …